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IL-2 + Radiotherapy + Pembrolizumab for Refractory Cancers
Study Summary
This trial is testing a new combination therapy for cancer that includes immunotherapy, radiation, and a new drug. It is designed to find the best dose of the new drug and to see if the combination therapy is safe and works better than current treatments.
- Non-Small Cell Lung Cancer
- Melanoma
- Kidney Cancer
- Head and Neck Squamous Cell Carcinoma
Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- You have had a lung condition called pneumonitis that needed treatment with steroids in the past, or you currently have pneumonitis.You have been diagnosed with HIV.You currently have Hepatitis B or Hepatitis C.You have at least one specific area that can be measured to see if the treatment is working.You are expected to live for at least 6 more months.You have a current infection that needs treatment with medication throughout your whole body.You have severe side effects from a previous treatment with PD-1 or PD-L1 drugs that have not gone away.You have another type of cancer that is getting worse or needs treatment.You have metastases in your brain or have carcinomatous meningitis.You have an ongoing autoimmune disease that needed strong medication in the last 2 years.You have had a serious autoimmune disease in the past.Your blood pressure is at least 80 when the heart is pumping.You cannot tolerate the type of medication being used in the study.You have had active tuberculosis in the past.You have a condition that weakens your immune system, or you are taking strong medicines that suppress your immune system within 7 days before starting the trial treatment.You have a disease that is not under control.Your organs must be working well, as shown in Table 2. All required lab tests must be done within 10 days before starting the treatment.You can join the study if you have a history of hypothyroidism and are taking a stable dose of thyroid replacement hormone.Adults 18 years or older with confirmed advanced lung, skin, kidney, or head and neck cancer.You do not have any other current cancer.You have taken strong medications that lower your immune system in the past 4 weeks.You didn't get better from a certain type of cancer treatment, or you got better at first but then got worse again.You are physically able to do light activities or work.You have a tumor that can be safely treated with radiotherapy and injections.Women who could become pregnant need to have a negative pregnancy test within 72 hours before starting the study medication.You are allergic to pembrolizumab or any of the ingredients in it.You have received another type of cancer treatment within 4 weeks before the study, or you have not recovered from side effects of a previous treatment given more than 4 weeks ago.
- Group 1: Pembrolizumab/IL-2/Radiotherapy
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
For what reasons is radiation therapy typically recommended?
"Radiotherapy can be used to target and shrink malignant neoplasms, unresectable melanoma, and tumours with high microsatellite instability."
To what extent has Radiotherapy been explored in other research projects?
"Currently, there are one thousand ongoing clinical trials observing the effects of Radiotherapy. Out of these, 122 have reached Phase 3 testing. Many of the participating facilities for these tests are based in Houston, Texas; though, there are a total 36030 locations running trials for Radiotherapy throughout the world."
Are we still looking for more participants in this experiment?
"Unfortunately, this study is not admitting patients at the moment. The listing was created on May 20th, 2019 and last updated February 17th, 2022. If you are looking for other trials, 3463 studies involving oral squamous cell carcinoma and 1000 trials testing radiotherapy treatments are currently recruiting participants."
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