← Back to Search

Anti-metabolites

Paclitaxel/Carboplatin and radiation for Uterine Cancer

Phase 1 & 2
Waitlist Available
Led By Karin Shih, MD
Research Sponsored by Northwell Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years post diagnosis
Awards & highlights

Study Summary

This trial will test the effectiveness of a new chemotherapy regimen for uterine serous carcinoma, which is an aggressive type of endometrial cancer that is difficult to treat.

Eligible Conditions
  • Uterine Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years post diagnosis
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years post diagnosis for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Feasibility of above regimen in women with advanced stage USC
Incidence of Treatment-related Adverse Events
Secondary outcome measures
Patient quality of life

Trial Design

1Treatment groups
Experimental Treatment
Group I: Paclitaxel/Carboplatin and radiationExperimental Treatment2 Interventions
Paclitaxel 135 mg/m2 over 3 hrs on day 1 Carboplatin IP (AUC= 6.0) on day 1 Paclitaxel 60 mg/m2 IP on Day 8 Repeat q 21 days x 6 cycles Pelvic 6MV Photon Beam Energy, or IMRT where appropriate 1.8 Gy Dose/FX Total Dose 45 Gy High Dose Radiation (HDR) x 3, or IMRT where appropriate 5 Gy to 0.5cm Depth from the Vaginal Cylinder Surface Total Dose 15 Gy
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Paclitaxel/Carboplatin
2009
Completed Phase 2
~90

Find a Location

Who is running the clinical trial?

Northwell HealthLead Sponsor
458 Previous Clinical Trials
470,933 Total Patients Enrolled
Karin Shih, MDPrincipal InvestigatorNorthwell Health

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research project allow elderly individuals to participate?

"In order to be included in this clinical trial, patients must be aged 18 to 99. Out of the 3735 total trials, 151 are for people under 18 and 3735 are for patients over 65."

Answered by AI

Are we able to sign people up for this trial at the moment?

"The information available on clinicaltrials.gov does specify that this trial is open and recruiting patients. This particular trial was first posted on May 20th, 2020 with the most recent update being November 16th, 2021. So far, only 17 individuals have been enrolled at a single site."

Answered by AI

Could you tell me how many people are involved in this clinical trial?

"Yes, the clinicaltrial.gov website verifies that this trial is still actively searching for participants. The posting date was May 20th 2020 with the most recent update on November 16th 2021. They are hoping to enroll 17 subjects from a single location."

Answered by AI

Is this treatment backed by other scientific research?

"There are currently 1229 trials studying this treatment with 343 of them being in Phase 3. The majority of these clinical studies are based in Shanghai, but there are 67003 locations running trials for this treatment."

Answered by AI

Are there any medical prerequisites for this clinical study?

"Carcinoma patients between the ages of 18 and 99 are encouraged to apply for this clinical trial. In addition to carcinoma, eligible patients must also have definitive USC diagnosis determined by a previous procedure. At the discretion of the surgeon, complete surgical staging should include: total hysterectomy, bilateral salpingo-oophorectomy, peritoneal washings, omental biopsy and lymph node evaluation., ECOG performance status of ≤ 2., Residual disease at completion of surgery of ≤ 1cm by surgeon report., Age > 18 years.."

Answered by AI

What are the common reasons why this medication is given to patients?

"This medication is frequently used to treat melanoma, but it can also help patients with neoplasm metastasis, lymphoma, non-hodgkin, advanced sarcoma."

Answered by AI
~0 spots leftby Apr 2025