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CPAP Therapy for Asthma

Q: Does the age of participating volunteers exceed 25 years?

Those who meet the age criteria of 18-65 are eligible to apply for this clinical trial. There is an abundance of other studies available, with 113 trials dedicated to those under 18 and 198 researched geared towards individuals over 65 years old.

Q: How many individuals can participate in this research endeavor?

Affirmative, data hosted on clinicaltrials.gov verifies that this medical experiment is presently seeking recruits. The investigation was published on May 7th 2018 and last modified on May 26th 2022; it requires 40 volunteers from a single site.

Q: What set of qualifications must a person meet to participate in this research?

The eligibility criteria for this trial necessitate that candidates are aged 18 to 65 and have <a href="https://www.withpower.com/clinical-trials/asthma">asthma</a>. A total of 40 individuals can join the study.

Q: Is recruitment still active for this research study?

Affirmative. Clinicaltrials.gov reveals that this research, which was initially made available on 05/07/2018 is presently recruiting individuals for participation. The trial requires 40 volunteers from a single medical facility to be enrolled in the study prior to completion.

Phase 1 & 2

Recruiting

Led By Anne Dixon, BM BCh

Research Sponsored by University of Vermont

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Ages 18-65 years

Physician diagnosis of asthma

Timeline

Screening 3 weeks

Treatment Varies

Follow Up through study completion, an average of one week

Awards & highlights

Study Summary

This trial will test whether or not CPAP can be an effective controller therapy for asthma in people with a BMI of 30 kg/m2 or higher. The trial will have two phases, with the first phase determining the optimal duration of CPAP, and the second phase testing CPAP against a sham device in a controlled setting.

Who is the study for?

This trial is for adults aged 18-65 with asthma and a BMI of 30 or higher. Participants must have a physician's diagnosis of asthma, specific lung responsiveness to methacholine (PC20 < 16 mg/ml), and relatively low allergy antibody levels (IgE < 100 IU/ml). Healthy individuals without asthma but with similar BMI can also participate as controls.Check my eligibility

What is being tested?

The study is testing if CPAP, which increases lung volume by providing positive expiratory pressure, can help control asthma in overweight patients. It has two parts: first finding the best duration for CPAP use, then comparing real CPAP against sham (fake) treatment in a blinded experiment where neither participants nor researchers know who gets which until after the results are collected.See study design

What are the potential side effects?

While not specified here, common side effects of using CPAP may include discomfort or irritation at the mask site, dry nose or throat, headaches, bloating and difficulty falling asleep initially.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 65 years old.

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I have been diagnosed with asthma by a doctor.

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I have never been diagnosed with asthma by a doctor.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ through study completion, an average of one week

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~through study completion, an average of one week

This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of one week for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in impedance of lung in response to methacholine measured by forced oscillation

Secondary outcome measures

Change in asthma control

Change in spirometric lung function (FEV1 and FVC)

Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: CPAP 10Active Control1 Intervention

Participants will be randomized to CPAP 10

Group II: Sham CPAPPlacebo Group1 Intervention

Participants will be randomized to Sham CPAP

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Icahn School of Medicine at Mount SinaiOTHER

860 Previous Clinical Trials

524,436 Total Patients Enrolled

12 Trials studying Asthma

9,133 Patients Enrolled for Asthma

University of VermontLead Sponsor

267 Previous Clinical Trials

3,743,701 Total Patients Enrolled

9 Trials studying Asthma

4,729 Patients Enrolled for Asthma

Anne Dixon, BM BCh3.02 ReviewsPrincipal Investigator - University of Vermont

University of Vermont

1 Previous Clinical Trials

20 Total Patients Enrolled

1 Trials studying Asthma

20 Patients Enrolled for Asthma

Media Library

CPAP (Other) Clinical Trial Eligibility Overview. Trial Name: NCT02953431 — Phase 1 & 2

Asthma Research Study Groups: Sham CPAP, CPAP 10

Asthma Clinical Trial 2023: CPAP Highlights & Side Effects. Trial Name: NCT02953431 — Phase 1 & 2

CPAP (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02953431 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does the age of participating volunteers exceed 25 years?

"Those who meet the age criteria of 18-65 are eligible to apply for this clinical trial. There is an abundance of other studies available, with 113 trials dedicated to those under 18 and 198 researched geared towards individuals over 65 years old."

Answered by AI

How many individuals can participate in this research endeavor?

"Affirmative, data hosted on clinicaltrials.gov verifies that this medical experiment is presently seeking recruits. The investigation was published on May 7th 2018 and last modified on May 26th 2022; it requires 40 volunteers from a single site."

Answered by AI

What set of qualifications must a person meet to participate in this research?

"The eligibility criteria for this trial necessitate that candidates are aged 18 to 65 and have asthma. A total of 40 individuals can join the study."

Answered by AI

Is recruitment still active for this research study?

"Affirmative. Clinicaltrials.gov reveals that this research, which was initially made available on 05/07/2018 is presently recruiting individuals for participation. The trial requires 40 volunteers from a single medical facility to be enrolled in the study prior to completion."

Answered by AI

Recent research and studies

RespirologyJournal

Influence of Distinct Asthma Phenotypes on Lung Function Following Weight Loss in the Obese

Chapman, David G., Charles G. Irvin, David A. Kaminsky, Patrick M. Forgione, Jason H.T. Bates, and Anne E. Dixon. 2014. “Influence of Distinct Asthma Phenotypes on Lung Function Following Weight Loss in the Obese”. Respirology. Wiley. doi:10.1111/resp.12368.

Journal of Applied PhysiologyJournal

Potential Role of the Airway Wall in the Asthma of Obesity

Bates, Jason H. T., and Anne E. Dixon. 2015. “Potential Role of the Airway Wall in the Asthma of Obesity”. Journal of Applied Physiology. American Physiological Society. doi:10.1152/japplphysiol.00684.2014.

American Journal of Respiratory and Critical Care MedicineJournal

The Nonallergic Asthma of Obesity. A Matter of Distal Lung Compliance

Al-Alwan, Ali, Jason H. T. Bates, David G. Chapman, David A. Kaminsky, Michael J. DeSarno, Charles G. Irvin, and Anne E. Dixon. 2014. “The Nonallergic Asthma of Obesity. A Matter of Distal Lung Compliance”. American Journal of Respiratory and Critical Care Medicine. American Thoracic Society. doi:10.1164/rccm.201401-0178oc.

clinicaltrials.govStudy