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Cenicriviroc for HIV-Related Inflammation
Study Summary
This trial will test if a drug can reduce inflammation in the aorta, as seen using imaging techniques.
Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I have undergone radiation therapy in the past.I have not been vaccinated within the week before my PET/CT scan.I expect to start taking medication to lower my cholesterol during the study.I haven't taken any immune system modifying drugs in the last 30 days.My recent PET/CT scan is clear and approved for study use.I have severe liver problems, including fluid buildup, confusion, or bleeding veins in my stomach.You have a confirmed HIV-1 infection.I haven't taken any medications that could interact with CVC in the last 90 days.My body weight is over 300 pounds or 136 kilograms.I am currently taking high doses of Atorvastatin or Rosuvastatin.I have been diagnosed with a specific infection like TB or toxoplasmosis in the last 3 months.I've been on a stable HIV treatment for over 48 weeks without major interruptions.I have untreated hepatitis B with detectable virus in the last 6 months.Your recent blood and kidney function tests should be within normal range.I have a heart risk like high blood pressure, diabetes, or a family history of heart disease.You have a current hepatitis C virus (HCV) infection.I've had more than two high radiation procedures in the last year.Your HIV levels have been very low for the past 48 weeks before joining the study.I haven't had a serious infection or illness that needed IV antibiotics or hospitalization in the last 3 months.I have or had tuberculosis that was not fully treated.I have not had a heart attack or unstable angina in the last 90 days.I won't get vaccines 7 days before my 24-week study visit.Your HIV test shows very low or undetectable levels of the virus.You have a certain amount of a type of white blood cell called CD4+ cells in your body.I have an active cancer other than squamous cell skin cancer.I am 45 years old or older.Your average blood sugar level (Hemoglobin A1c) is higher than 8% within the last 90 days.I have not started or changed my statin medication in the last 90 days.
- Group 1: CVC arm (Arm A)
- Group 2: Placebo for CVC arm (Arm B)
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What potential hazards might patients face while undergoing treatment in Arm A of this CVC trial?
"Our organisation has assigned a score of 2 to the CVC arm (Arm A) due to there being some evidence supporting safety, but no data yet demonstrating efficacy."
What is the scope of this trial's implementation?
"The trial is actively enrolling participants at three different locations: Harbor University of California Los Angeles Center CRS (Site # 603) in Torrance, Pennsylvania; University of Pittsburgh CRS (Site # 1001) in Pittsburgh, Ohio; and Case CRS (Site # 2501) in Cleveland, New york. Additionally, 17 other sites are also involved."
Is this research project recruiting participants currently?
"As indicated on clinicaltrials.gov, this medical trial is not actively seeking participants at the time being; it was first published on February 20th of 2021 and updated lastly November 22nd 2022. Although enlistment has ended for the current study, over 480 other trials are open to applicants presently."
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