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Weight Loss for Obesity (RISE Trial)

Phase 2 & 3
Waitlist Available
Led By Leslie Ira Katzel, MD PhD
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 3 months, 6 months, 12 months, 24 months
Awards & highlights

RISE Trial Summary

This study is evaluating whether a multi-modal balance intervention can improve fitness, functional performance, balance, and economy of gait in older adults.

Eligible Conditions
  • Obesity
  • Dysmobility Syndrome

RISE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 3 months, 6 months, 12 months, 24 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 3 months, 6 months, 12 months, 24 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in 6 minute walk distance
Secondary outcome measures
Change in 6 minute walk with VO2 measurement
Change in 8 foot up and go
Change in ADL/IADL questionnaire
+9 more

RISE Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Multi Modal Balance Training & Weight LossExperimental Treatment2 Interventions
Supervised exercise 3 times per week for about 1 hour. The classes will consist of a group balance class (about 30 minutes), a supervised obstacle course (about 10 minutes), and lower body and core body strength exercises (about 20 minutes). Weekly nutrition sessions for individual dietary recommendations designed to produce about a 10% weight loss over the first six months of the study.
Group II: Multi Modal Balance Training OnlyActive Control1 Intervention
Supervised exercise 3 times per week for about 1 hour. The classes will consist of a group balance class (about 30 minutes), a supervised obstacle course (about 10 minutes), and lower body and core body strength exercises (about 20 minutes).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Multi Modal Balance Training
2016
Completed Phase 3
~40
Weight Loss
2008
Completed Phase 3
~1460

Find a Location

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,611 Previous Clinical Trials
3,305,247 Total Patients Enrolled
40 Trials studying Obesity
10,050 Patients Enrolled for Obesity
Leslie Ira Katzel, MD PhDPrincipal InvestigatorBaltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
1 Previous Clinical Trials
41 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
Maryland
How old are they?
18 - 65
What site did they apply to?
Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Multimodel Exercise and Weight Loss in Older Obese Veterans With Dysmobility
2016. "Multimodel Exercise and Weight Loss in Older Obese Veterans With Dysmobility". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02806336.
~4 spots leftby Apr 2025
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