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5-HTP + Carbidopa for Spinal Cord Injury (5-HTP only Trial)
5-HTP only Trial Summary
This trial will study the effects of 5-HTP on nerve function and movement in people with spinal cord injuries of varying degrees of severity.
5-HTP only Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria below5-HTP only Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.5-HTP only Trial Design
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- I have had tumors in the past.I have kidney problems.Low levels of calcium in your blood.I had a spinal cord injury more than six months ago.You have nerve damage outside of the spinal cord.I have a history of seizures or epilepsy.I have a hormone gland problem.I am currently taking medication that affects my central nervous system.My bone marrow is not functioning properly.I am currently taking levodopa.I have been diagnosed with wide angle glaucoma.I have a history of heart disease, including heart attacks or irregular heartbeats.I have had stomach ulcers in the past.My liver is not working properly.I am currently taking medication for depression or Parkinson's disease.I have been diagnosed with coronary artery disease.I have heart problems that are not well-managed.I am currently taking medication that affects serotonin levels.I am currently taking iron supplements.I am currently taking medication for high blood pressure.I am not in a coma or severely depressed due to medications.You have had thoughts of hurting yourself or others in the past.I am currently taking lithium.People who drink alcohol.I have been diagnosed with phenylketonuria.I am currently taking antidepressants that affect serotonin.You have a mental health condition that is not stable.I am currently taking amphetamine.I am currently taking metoclopramide.I have a blood disorder.I am currently taking tricyclic antidepressants.I am currently taking phenothiazine medication.I have a lung condition.I am currently taking medication that affects dopamine in my brain.I had a spinal cord injury more than six months ago.
- Group 1: Carbidopa
- Group 2: High-dose 5HTP
- Group 3: Low-dose 5HTP
- Group 4: Placebo
- Approved for 10 Other Conditions - This treatment demonstrated efficacy for 10 other conditions.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there other cases where 5HTP has been studied at a small dosage?
"5HTP was first studied at Academic Medical Center in 2014. Since then, there have been 18335 completed studies. As of now, there are 14 active clinical trials, with many of these taking place in Edmonton, Alberta."
How is 5HTP commonly employed in patients?
"A standard treatment for parkinsonism post encephalitic is Low-dose 5HTP. This medication is also commonly used to mitigate the symptoms of parkinson disease, manganese intoxication, and levodopa-driven nausea and vomiting."
Are there any prerequisites to enrolling in this research project?
"Up to 30 patients that have experienced a spinal cord injury, and are between 18-65 years old, can participate in this study. Key inclusion criteria for patients include: participants must have suffered their spinal cord injury at least six months ago."
Are there any available slots for this research project?
"You are correct, the clinical trial described is not currently enrolling patients. The trial was posted on 2020-07-01 and updated on 2022-10-13, according to clinicaltrials.gov. There are, however, 384 other trials that are still recruiting."
What are the benefits that researchers hope to gain from this clinical trial?
"The primary objectives of this study, which will be measured at pre-drug baseline and 120-150 minutes post-drug administration, is to investigate changes in motoneuron excitability. Secondary outcome measures include 5HIAA (serum), 5-HT (serum and whole blood), cortisol, and serum cortisol levels."
Will this experiment be testing any treatments on elderly individuals?
"Eligibility criteria for this study includes being between 18-65 years old."
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