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Opioid Analgesic
Remifentanil Hydrochloride for Respiratory Depression
Phase 2 & 3
Recruiting
Led By Rachel Eshima McKay, MD
Research Sponsored by University of California, San Francisco
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, and every 2.5 minutes during 10-minute infusion and 25-minute recovery
Awards & highlights
Study Summary
This trial will study the effects of opioids on the pupils of people aged 40 to 60, to see if it is a good indicator of opioid toxicity and respiratory depression in this age group.
Eligible Conditions
- Respiratory Depression
- Constricted Pupils
- Opioid Overdose
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline, and every 2.5 minutes during 10-minute infusion and 25-minute recovery
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, and every 2.5 minutes during 10-minute infusion and 25-minute recovery
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Area Under the Time Concentration Curve (AUC 0-35 minutes)
Trial Design
2Treatment groups
Experimental Treatment
Group I: Noninteractive, then InteractiveExperimental Treatment2 Interventions
Participants undergo the infusion under noninteractive conditions, followed by a second drug infusion under interactive conditions.
Group II: Interactive, then NoninteractiveExperimental Treatment2 Interventions
Participants undergo the infusion under interactive conditions, followed by a second drug infusion under noninteractive conditions.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Remifentanil
FDA approved
Find a Location
Who is running the clinical trial?
University of California, San FranciscoLead Sponsor
2,505 Previous Clinical Trials
15,237,535 Total Patients Enrolled
1 Trials studying Respiratory Depression
20 Patients Enrolled for Respiratory Depression
Rachel Eshima McKay, MDPrincipal InvestigatorProfessor of Anesthesia
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there any requirements to join this clinical research?
"20 participants, who must be between 40-60 years old and have miosis disorder, are needed for this study. Furthermore, these individuals must also be considered healthy with a BMI lower than 35 kg/m2."
Answered by AI
Does this research involve seniors as participants?
"This particular trial is only open to adults aged 40-60. Out of the 30 trials for those under 18 and 167 for seniors, this is the only one that falls in the middle age range."
Answered by AI
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