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Estrogen

Young postmenopausal women for Healthy Subjects

Phase 2 & 3
Waitlist Available
Led By Janet E Hall, M.D.
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up peak hormone level within 2 hours post gnrh doses
Awards & highlights

Study Summary

The purpose of this study is to study the effects of aging and estrogen on the brain. Specifically, this study will examine how the hypothalamus signals the pituitary gland to secrete reproductive hormones and how that changes with aging.

Eligible Conditions
  • Healthy Subjects

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~peak hormone level within 2 hours post gnrh doses
This trial's timeline: 3 weeks for screening, Varies for treatment, and peak hormone level within 2 hours post gnrh doses for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Effect of Estrogen on Pituitary Response to GnRH
Pituitary Response to GnRH

Trial Design

2Treatment groups
Experimental Treatment
Group I: Young postmenopausal womenExperimental Treatment3 Interventions
intervention: graded doses of GnRH following NAL-GLU GnRH antagonist administration with or without transdermal estrogen patch
Group II: Older postmenopausal womenExperimental Treatment3 Interventions
intervention: graded doses of GnRH following NAL-GLU GnRH antagonist administration with or without transdermal estrogen patch
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Gonadorelin
FDA approved
Estradiol
FDA approved

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,932 Previous Clinical Trials
13,198,476 Total Patients Enrolled
National Institute on Aging (NIA)NIH
1,672 Previous Clinical Trials
28,018,644 Total Patients Enrolled
Janet E Hall, M.D.Principal InvestigatorMassachusetts General Hospital
10 Previous Clinical Trials
26,712 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
The Effects of Aging and Estrogen on the Pituitary
Janet E. Hall, MD 2002. "The Effects of Aging and Estrogen on the Pituitary". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00386022.
All > Growth Hormone Deficiency
~1 spots leftby Apr 2025
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