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Virus Therapy

Offer of Vaginal Self Collection for Human Papillomavirus

Phase 2 & 3
Waitlist Available
Led By Alice Lytwyn, MD, FRCPC
Research Sponsored by McMaster University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 18 months
Awards & highlights

Study Summary

Up to 30% of Canadian women do not participate in Pap smear screening for cervical cancer prevention despite many being members of family practices and having access to family physicians. One reason is reluctance to undergo pelvic examination. The investigators purpose is to determine whether the offer of vaginal self sample collection for oncogenic human papillomavirus (HPV) testing increases participation in cervical cancer screening compared to repeat reminder for Pap smear testing among female family practice members who have not previously responded to invitations for Pap testing.

Eligible Conditions
  • Human Papillomavirus
  • Cervical Neoplasia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~18 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 18 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
uptake of screening invitation
Secondary outcome measures
Cervical Intraepithelial Neoplasia (CIN) 3 identified

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Offer of Vaginal Self CollectionExperimental Treatment2 Interventions
50% of study participants who are overdue for Pap testing and do not respond to initial reminder letter will be selected to be mailed a second reminder letter and offer of vaginal self collection
Group II: 2nd Reminder LetterActive Control1 Intervention
50% of study participants who are overdue for Pap testing and do not respond to initial reminder letter will be be mailed a standard second reminder letter

Find a Location

Who is running the clinical trial?

McMaster UniversityLead Sponsor
880 Previous Clinical Trials
2,596,388 Total Patients Enrolled
Juravinski Cancer Centre FoundationOTHER
11 Previous Clinical Trials
477 Total Patients Enrolled
Public Health Agency of Canada (PHAC)OTHER_GOV
45 Previous Clinical Trials
95,693 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
California
How old are they?
18 - 65
What site did they apply to?
McMaster University
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Randomized Trial of Vaginal Self Sampling for Human Papillomavirus (HPV)
2010. "Randomized Trial of Vaginal Self Sampling for Human Papillomavirus (HPV)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01095198.
All > Hpv
~96 spots leftby Apr 2025
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