Online Behavioral Weight Loss Program for Overweight

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Overweight+2 More
Online Behavioral Weight Loss Program - Behavioral
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial will use MOST to determine which of 5 innovative intervention components, alone or in combination, is most effective in helping people lose weight.

Eligible Conditions
  • Overweight
  • Obesity

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

2 Primary · 7 Secondary · Reporting Duration: 12-month end of treatment

12-month end of treatment
Dietary energy density
Dietary quality
Internal disinhibition
Mean weight change (percent of initial body weight)
Proportion of participants achieving at least 5% weight loss
Social support for diet and exercise behaviors
Structured physical activity
Supportive accountability
Weight loss self-efficacy

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

32 Treatment Groups

Social Support, Dysregulated Eating, Feedback, VR
1 of 32
Social Support, Dysregulated Eating, Exercise, Feedback
1 of 32
Social Support, Exercise, Feedback
1 of 32
Dysregulated Eating
1 of 32
Exercise
1 of 32
Dysregulated Eating, Exercise, VR
1 of 32
Social Support, Dysregulated Eating, Exercise, Feedback, VR
1 of 32
Social Support, Dysregulated Eating
1 of 32
Feedback
1 of 32
Dysregulated Eating, VR
1 of 32
Dysregulated Eating, Exercise, Feedback, VR
1 of 32
Exercise, Feedback
1 of 32
Dysregulated Eating, Feedback, VR
1 of 32
Social Support, Dysregulated Eating, Feedback
1 of 32
Dysregulated Eating, Feedback
1 of 32
Social Support, Exercise, VR
1 of 32
Feedback, VR
1 of 32
VR
1 of 32
Core Program Only
1 of 32
Exercise, VR
1 of 32
Social Support, Dysregulated Eating, Exercise
1 of 32
Social Support
1 of 32
Social Support, Exercise
1 of 32
Dysregulated Eating, Exercise
1 of 32
Social Support, Feedback, VR
1 of 32
Social Support, Dysregulated Eating, Exercise, VR
1 of 32
Exercise, Feedback, VR
1 of 32
Social Support, Dysregulated Eating, VR
1 of 32
Dysregulated Eating, Exercise, Feedback
1 of 32
Social Support, Exercise, Feedback, VR
1 of 32
Social Support, Feedback
1 of 32
Social Support, VR
1 of 32
Experimental Treatment

384 Total Participants · 32 Treatment Groups

Primary Treatment: Online Behavioral Weight Loss Program · No Placebo Group · Phase 2 & 3

Social Support, Dysregulated Eating, Feedback, VRExperimental Group · 5 Interventions: Online Behavioral Weight Loss Program, Virtual Reality for Behavioral Weight Loss Skills Training, Tailored Interactive Video Feedback, Skills Training for Dysregulated Eating, Platform for Social Support & Friendly Competition · Intervention Types: Behavioral, Behavioral, Behavioral, Behavioral, Behavioral
Social Support, Dysregulated Eating, Exercise, FeedbackExperimental Group · 5 Interventions: Online Behavioral Weight Loss Program, Tailored Interactive Video Feedback, Tailored Intervention for Structured Physical Activity, Skills Training for Dysregulated Eating, Platform for Social Support & Friendly Competition · Intervention Types: Behavioral, Behavioral, Behavioral, Behavioral, Behavioral
Social Support, Exercise, FeedbackExperimental Group · 4 Interventions: Online Behavioral Weight Loss Program, Tailored Interactive Video Feedback, Tailored Intervention for Structured Physical Activity, Platform for Social Support & Friendly Competition · Intervention Types: Behavioral, Behavioral, Behavioral, Behavioral
Dysregulated EatingExperimental Group · 2 Interventions: Online Behavioral Weight Loss Program, Skills Training for Dysregulated Eating · Intervention Types: Behavioral, Behavioral
ExerciseExperimental Group · 2 Interventions: Online Behavioral Weight Loss Program, Tailored Intervention for Structured Physical Activity · Intervention Types: Behavioral, Behavioral
Dysregulated Eating, Exercise, VRExperimental Group · 4 Interventions: Online Behavioral Weight Loss Program, Virtual Reality for Behavioral Weight Loss Skills Training, Tailored Intervention for Structured Physical Activity, Skills Training for Dysregulated Eating · Intervention Types: Behavioral, Behavioral, Behavioral, Behavioral
Social Support, Dysregulated Eating, Exercise, Feedback, VRExperimental Group · 6 Interventions: Online Behavioral Weight Loss Program, Virtual Reality for Behavioral Weight Loss Skills Training, Tailored Interactive Video Feedback, Tailored Intervention for Structured Physical Activity, Skills Training for Dysregulated Eating, Platform for Social Support & Friendly Competition · Intervention Types: Behavioral, Behavioral, Behavioral, Behavioral, Behavioral, Behavioral
Social Support, Dysregulated EatingExperimental Group · 3 Interventions: Online Behavioral Weight Loss Program, Skills Training for Dysregulated Eating, Platform for Social Support & Friendly Competition · Intervention Types: Behavioral, Behavioral, Behavioral
FeedbackExperimental Group · 2 Interventions: Online Behavioral Weight Loss Program, Tailored Interactive Video Feedback · Intervention Types: Behavioral, Behavioral
Dysregulated Eating, VRExperimental Group · 3 Interventions: Online Behavioral Weight Loss Program, Virtual Reality for Behavioral Weight Loss Skills Training, Skills Training for Dysregulated Eating · Intervention Types: Behavioral, Behavioral, Behavioral
Dysregulated Eating, Exercise, Feedback, VRExperimental Group · 5 Interventions: Online Behavioral Weight Loss Program, Virtual Reality for Behavioral Weight Loss Skills Training, Tailored Interactive Video Feedback, Tailored Intervention for Structured Physical Activity, Skills Training for Dysregulated Eating · Intervention Types: Behavioral, Behavioral, Behavioral, Behavioral, Behavioral
Exercise, FeedbackExperimental Group · 2 Interventions: Online Behavioral Weight Loss Program, Tailored Interactive Video Feedback · Intervention Types: Behavioral, Behavioral
Dysregulated Eating, Feedback, VRExperimental Group · 4 Interventions: Online Behavioral Weight Loss Program, Virtual Reality for Behavioral Weight Loss Skills Training, Tailored Interactive Video Feedback, Skills Training for Dysregulated Eating · Intervention Types: Behavioral, Behavioral, Behavioral, Behavioral
Social Support, Dysregulated Eating, FeedbackExperimental Group · 4 Interventions: Online Behavioral Weight Loss Program, Tailored Interactive Video Feedback, Skills Training for Dysregulated Eating, Platform for Social Support & Friendly Competition · Intervention Types: Behavioral, Behavioral, Behavioral, Behavioral
Dysregulated Eating, FeedbackExperimental Group · 3 Interventions: Online Behavioral Weight Loss Program, Tailored Interactive Video Feedback, Skills Training for Dysregulated Eating · Intervention Types: Behavioral, Behavioral, Behavioral
Social Support, Exercise, VRExperimental Group · 4 Interventions: Online Behavioral Weight Loss Program, Virtual Reality for Behavioral Weight Loss Skills Training, Tailored Intervention for Structured Physical Activity, Platform for Social Support & Friendly Competition · Intervention Types: Behavioral, Behavioral, Behavioral, Behavioral
Feedback, VRExperimental Group · 3 Interventions: Online Behavioral Weight Loss Program, Virtual Reality for Behavioral Weight Loss Skills Training, Tailored Interactive Video Feedback · Intervention Types: Behavioral, Behavioral, Behavioral
VRExperimental Group · 2 Interventions: Online Behavioral Weight Loss Program, Virtual Reality for Behavioral Weight Loss Skills Training · Intervention Types: Behavioral, Behavioral
Core Program Only
Behavioral
Experimental Group · 1 Intervention: Online Behavioral Weight Loss Program · Intervention Types: Behavioral
Exercise, VRExperimental Group · 3 Interventions: Online Behavioral Weight Loss Program, Virtual Reality for Behavioral Weight Loss Skills Training, Tailored Intervention for Structured Physical Activity · Intervention Types: Behavioral, Behavioral, Behavioral
Social Support, Dysregulated Eating, ExerciseExperimental Group · 4 Interventions: Online Behavioral Weight Loss Program, Tailored Intervention for Structured Physical Activity, Skills Training for Dysregulated Eating, Platform for Social Support & Friendly Competition · Intervention Types: Behavioral, Behavioral, Behavioral, Behavioral
Social SupportExperimental Group · 2 Interventions: Online Behavioral Weight Loss Program, Platform for Social Support & Friendly Competition · Intervention Types: Behavioral, Behavioral
Social Support, ExerciseExperimental Group · 3 Interventions: Online Behavioral Weight Loss Program, Tailored Intervention for Structured Physical Activity, Platform for Social Support & Friendly Competition · Intervention Types: Behavioral, Behavioral, Behavioral
Dysregulated Eating, ExerciseExperimental Group · 3 Interventions: Online Behavioral Weight Loss Program, Tailored Intervention for Structured Physical Activity, Skills Training for Dysregulated Eating · Intervention Types: Behavioral, Behavioral, Behavioral
Social Support, Feedback, VRExperimental Group · 4 Interventions: Online Behavioral Weight Loss Program, Virtual Reality for Behavioral Weight Loss Skills Training, Tailored Interactive Video Feedback, Platform for Social Support & Friendly Competition · Intervention Types: Behavioral, Behavioral, Behavioral, Behavioral
Social Support, Dysregulated Eating, Exercise, VRExperimental Group · 5 Interventions: Online Behavioral Weight Loss Program, Virtual Reality for Behavioral Weight Loss Skills Training, Tailored Intervention for Structured Physical Activity, Skills Training for Dysregulated Eating, Platform for Social Support & Friendly Competition · Intervention Types: Behavioral, Behavioral, Behavioral, Behavioral, Behavioral
Exercise, Feedback, VRExperimental Group · 4 Interventions: Online Behavioral Weight Loss Program, Virtual Reality for Behavioral Weight Loss Skills Training, Tailored Interactive Video Feedback, Tailored Intervention for Structured Physical Activity · Intervention Types: Behavioral, Behavioral, Behavioral, Behavioral
Social Support, Dysregulated Eating, VRExperimental Group · 4 Interventions: Online Behavioral Weight Loss Program, Virtual Reality for Behavioral Weight Loss Skills Training, Skills Training for Dysregulated Eating, Platform for Social Support & Friendly Competition · Intervention Types: Behavioral, Behavioral, Behavioral, Behavioral
Dysregulated Eating, Exercise, FeedbackExperimental Group · 4 Interventions: Online Behavioral Weight Loss Program, Tailored Interactive Video Feedback, Tailored Intervention for Structured Physical Activity, Skills Training for Dysregulated Eating · Intervention Types: Behavioral, Behavioral, Behavioral, Behavioral
Social Support, Exercise, Feedback, VRExperimental Group · 5 Interventions: Online Behavioral Weight Loss Program, Virtual Reality for Behavioral Weight Loss Skills Training, Tailored Interactive Video Feedback, Tailored Intervention for Structured Physical Activity, Platform for Social Support & Friendly Competition · Intervention Types: Behavioral, Behavioral, Behavioral, Behavioral, Behavioral
Social Support, FeedbackExperimental Group · 3 Interventions: Online Behavioral Weight Loss Program, Tailored Interactive Video Feedback, Platform for Social Support & Friendly Competition · Intervention Types: Behavioral, Behavioral, Behavioral
Social Support, VRExperimental Group · 3 Interventions: Online Behavioral Weight Loss Program, Virtual Reality for Behavioral Weight Loss Skills Training, Platform for Social Support & Friendly Competition · Intervention Types: Behavioral, Behavioral, Behavioral
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Online Behavioral Weight Loss Program
2021
N/A
~60

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 12-month end of treatment

Who is running the clinical trial?

The Miriam HospitalLead Sponsor
227 Previous Clinical Trials
36,007 Total Patients Enrolled
19 Trials studying Overweight
2,768 Patients Enrolled for Overweight

Eligibility Criteria

Age 18+ · All Participants · 10 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
I am not currently taking medication to lose weight.
Has not lost more than 5% of their body weight in the 6 months prior to enrolling.
in the study The person has not been pregnant in the previous 6 months.
or higher, able to communicate fluently with all agency staff Can communicate fluently with all agency staff who are English language literate and at the 6th grade level or higher.
to rest I can walk around two city blocks without stopping to rest.
The person is not currently participating in any other weight loss program.
She denies having any heart conditions, chest pain during activity or rest, or any episodes of loss of consciousness in the 12 months prior to enrolling.
This person denies any medical condition that would prevent them from safely participating in unsupervised physical activity.
You have a body mass index (BMI) between 25 and 50 kg/m-squared.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 7th, 2021

Last Reviewed: October 4th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

Who else is applying?

What state do they live in?
Rhode Island50.0%
Texas50.0%
How old are they?
18 - 65100.0%
What portion of applicants met pre-screening criteria?
Met criteria50.0%
Did not meet criteria50.0%
What site did they apply to?
Miriam Hospital Weight Control and Diabetes Resarch Center100.0%