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Benralizumab for Hypereosinophilic Syndrome (HESIL5R Trial)
HESIL5R Trial Summary
This trial is testing if the drug benralizumab can safely decrease eosinophils in people with HES.
HESIL5R Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.HESIL5R Trial Design
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Who is running the clinical trial?
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- You have had severe allergic reactions to previous antibody treatments, including certain medications used to treat immune system disorders.You have a current bacterial or viral infection, but you can join the study once the infection is gone.You received a treatment called intravenous immunoglobulin (IVIG) within the past 30 days before agreeing to participate in the study.You have had issues with drinking alcohol or using drugs in the past year.You have been treated with benralizumab (MEDI-563) before.You have a birth control implant called levonorgestrel.You are currently receiving injections of progestogen hormone.You have been diagnosed with lymphoma, blood cancer, or advanced and spreading solid tumors. You are currently receiving chemotherapy, radiotherapy, or interleukin 2 treatment.You have a type of birth control called an intrauterine device (IUD) that has a very low chance of failing (less than 1% chance).You need to use two forms of birth control, like a diaphragm or condom with spermicide, to prevent pregnancy during the study.
- Group 1: Drug
- Group 2: Placebo
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Does this experiment involve any geriatric individuals?
"This trial is available for people aged 18-75. There are 37 studies currently open for patients under the age of 18 and 72 for elderly patients over 65."
Who would be a good candidate for this clinical trial?
"This trial is currently recruiting 20 patients that have had respiratory system agents. The upper age limit for participants is 75 years old and the lower age limit is 18 years old. To be eligible for this study, potential subjects must meet the following requirements: Male or female subject greater than or equal to18 and less than or equal to 75 years of age at screening., Females of non-child-bearing potential are defined as females with functioning ovaries with a documented history of tubal ligation or hysterectomy or females who are post-menopausal, as defined by 12 months of spontaneous amenorrhea with an appropriate clinical"
Are people with the required medical conditions able to sign up for this trial right now?
"Yes, as of right now this study is not looking for any more patients. The study was originally posted on May 19th, 2014 but the information was most recently updated on January 20th, 2022. Even though this trial isn't currently recruiting, there are 99 other trials that are searching for participants."
How many people fit the inclusion criteria for this research project?
"This study has already completed recruitment for patients. The listing was first made on May 19th, 2014 and updated as recently as January 20th, 2022. If you are looking for similar studies, there are 79 respiratory system agents trials and 20 Drug trials currently recruiting participants."
What other similar trials exist for this purpose?
"Drug has been under clinical observation since 2014. The first trial was sponsored by AstraZeneca and took place that same year. After the initial study, which included 20 participants, Drug received approval for Phase 2 & 3 testing. Currently, there are 20 active studies involving Drug across 352 cities in 42 countries."
Are there other scientific investigations that have used Drug?
"At the moment, there are 20 ongoing clinical trials for Drug. Of these studies, 10 have reached Phase 3. It's worth noting that while a majority of these experiments are taking place in Bethesda, Maryland; 1481 research sites across the globe are conducting similar investigations."
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