Methylprednisolone Tablet for Wounds

Phase-Based Estimates
1
Effectiveness
2
Safety
Brielle Orthopedics, Brick, NJ
Wounds+2 More
Methylprednisolone Tablet - Drug
Eligibility
18+
All Sexes
Eligible conditions
Wounds

Study Summary

This study is evaluating whether steroids can improve range of motion and functional outcomes in non-operatively managed musculoskeletal injuries of the hand.

See full description

Eligible Conditions

  • Wounds
  • Wounds and Injuries
  • Hand Injuries
  • Finger Injuries

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Methylprednisolone Tablet will improve 14 primary outcomes and 3 secondary outcomes in patients with Wounds. Measurement will happen over the course of 12 weeks.

12 weeks
Complications
Edema Measurements
MCP, DIP, PIP of digits 2-5: Extension
MCP, DIP, PIP of digits 2-5: Flexion
MCP, DIP, PIP of digits 2-5: abduction
MCP, DIP, PIP of digits 2-5: adduction
Quick DASH Questionnaire
Thumb Opposition at MCP
Thumb extension at IP
Thumb flexion at IP
VAS Pain Scale
hand pronation
hand supination
wrist flexion
wrist radial deviation
wrist ulnar deviation
initial
wrist extension

Trial Safety

Safety Estimate

2 of 3
This is better than 68% of similar trials

Trial Design

2 Treatment Groups

Control Group
Steroid Group

This trial requires 60 total participants across 2 different treatment groups

This trial involves 2 different treatments. Methylprednisolone Tablet is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 & 3 and have had some early promising results.

Steroid Group
Drug
Patients receive 21 tablets of 4 mg methylprednisolone to be taken by mouth over a 6 week taper. Patients will be advised to not take other anti-inflammatory medications like NSAIDs.
Control Group
Other
Patients will recieve standard treatment that focuses on mobilization and stabilization using common techniques like buddy taping and splinting. Pain control will be managed using non-NSAID medications like Tylenol or opioid narcotics when deemed medically necessary.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 12 weeks
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 12 weeks for reporting.

Who is running the study

Principal Investigator
B. V.
Bobby Varghese, Co-Investigator
Robert Wood Johnson Barnabas Health

Closest Location

Brielle Orthopedics - Brick, NJ

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There is one eligibility criterion to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Patients with soft tissue injuries and stable fractures from the metacarpophalangeal joint to the distal phalanx

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What causes wounds?

Add answer

Wounds arise from damage to the skin, which is the result of trauma, bacterial infections, or other conditions, including ultraviolet radiation, insect bites and plant stings. The best management of wounds includes good hand washing and appropriate care of the wound, preferably by a specialist. Healing of the wound may take time, depending on the location, type and severity of the wound.

Unverified Answer

Can wounds be cured?

Add answer

There are several causes that can be the root cause for chronic wounds, including diabetes, immunosuppressed skin and underlying disease, such as inflammatory skin diseases. However, with proper wound care and good management, most wounds can be cured. The healing of chronic wounds will be improved and the length of wound duration will be shortened by the treatment strategies.

Unverified Answer

How many people get wounds a year in the United States?

Add answer

About 19.5 million Americans experience some kind of chronic wound of the lower extremities in a given year. This accounts for over one-third (31.5%) of American adults.

Unverified Answer

What is wounds?

Add answer

There is an urgent need to develop a national wound assessment instrument that is free to use and have a high degree of interpretation and reproducibility to use in clinical and research settings. This is of critical importance as in 2000, 827,910 people developed at least one acute wound. This was the highest rate for 10 years, and the highest rate for 1,100 years. The mean cost is estimated at £17,700.00-a huge sum. We therefore believe that the development of such a tool would be of enormous value in helping to benchmark priorities with the NHS.

Unverified Answer

What are the signs of wounds?

Add answer

Wounds are usually caused by trauma or penetration of a body part and typically produce bleeding. They can also produce signs of infection in most cases.

Unverified Answer

What are common treatments for wounds?

Add answer

The most common treatment for a burn is to treat the burn with topical antibacterials, use a bandage, or both. There are many types of dressings that can be used in addition to the above to give better coverage. Other treatments include topical wound spray or medications. When considering treatment, the patient's health and the amount of injury they will suffer are taken into account.

Unverified Answer

Have there been any new discoveries for treating wounds?

Add answer

This article will show how to use [Pentoxifylline, a blood pressure medication, to treat venous congestion under the arm of a patient who has had a heart attack, stroke, and a knee dislocation. Pentoxifylline is commonly given to patients to help them deal with the stress of having a heart attack, a stroke, or even after having been in a car crash or other auto accident. When you take it for your heart problems, it also helps keep your arms and legs stretched and supple while you're doing things out in the garden or on the patio. Taking pentoxyfylline also helps keep your blood pressure in check.

Unverified Answer

Have there been other clinical trials involving methylprednisolone tablet?

Add answer

In a recent study, findings of the present study demonstrate that the therapeutic effect of methylprednisolone is better than that of the placebo. Therefore, there is scope for using this drug in the treatment of patients with chronic ulcers and burns.

Unverified Answer

What is the average age someone gets wounds?

Add answer

[Wounds and their treatments have evolved over the years: in the 1950s and 1960s, medical procedures consisted of simply bandaging wounds. Today, people often complain of severe chronic wounds such as diabetic, pressure ulcers due to immobilizing, infected wounds (fungal, bacterial, and virus). They have become a large health burden on hospitals and government healthcare system, and they have prompted us to revisit wound management. The average age of a wound at its presentation to a family doctor in a big city like London is 61.7 years (55-69). In rural and remote Australian regions, the average age of presenting a wound is 67.4 years (57-72).

Unverified Answer

Does methylprednisolone tablet improve quality of life for those with wounds?

Add answer

MP was more effective than S alone in reducing pain, itch and swelling and was more effective than SP alone in relieving wound-related distress. MMP-9 was significantly increased after treatment with MP and SP, implying that these medications might not be detrimental to wounds. Patient-reported quality of life is increased after treatment with MP, but, overall, S seems to be as good as MP in these areas.

Unverified Answer

What is methylprednisolone tablet?

Add answer

Methylprednisolone, when prescribed at a fixed dose, decreases inflammation, increases cell-mediated immunity and decreases the incidence of nosocomial infection. In all our wounds, the effects of methylprednisolone outweighed the risks, and we no longer use antibiotics for the short term management of minor wounds. At our wound clinic, we also rely on the use of the oral prednisone taper rather than hospitalisation.

Unverified Answer

What is the latest research for wounds?

Add answer

The evidence supporting routine postoperative [pain management](https://www.withpower.com/clinical-trials/pain-management) is limited. The evidence for the use of nonsteroidal anti-inflammatory drugs in treating wound healing was conflicting with no evidence to support either use or effectiveness. The evidence for the prevention of chronic wound pain is scarce.

Unverified Answer
See if you qualify for this trial
Get access to this novel treatment for Wounds by sharing your contact details with the study coordinator.