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Propofol for Depression
Study Summary
This trial will compare how well two different doses of propofol work as an antidepressant, as well as any potential side effects.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I've tried at least 2 antidepressants in the last 2 years without success.I am 18-55 years old with depression or bipolar disorder, not responding to 2 meds, and have been depressed for 2-60 months.I have not had electroconvulsive therapy in the last 3 months.I am unable to understand or sign a consent form.My condition has lasted more than 2 months but less than 5 years.I use benzodiazepine, opioid, ACE inhibitor, or ARB medication daily.I have heart problems like angina or heart failure.My blood pressure or diabetes is not well-managed.I am between 18 and 55 years old.I have been diagnosed with major depressive disorder or bipolar disorder.I am currently experiencing a severe episode of depression.I am allergic to propofol, egg lecithin, soybean oil, or similar substances.ECT was not suitable for me or did not work well in the last 5 years.I have not had a traumatic brain injury or significant neurological issues in the past year.My kidney or liver is not functioning properly.
- Group 1: Propofol High Dose
- Group 2: Propofol Low Dose
- Approved for 10 Other Conditions - This treatment demonstrated efficacy for 10 other conditions.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Would this particular drug testing program be interested in candidates who are elderly?
"As this trial's inclusion criteria stipulate, the youngest patients that can enroll must be 18 years old whereas the oldest patients cannot exceed 55 years of age."
What is Propofol's standard purpose in a hospital setting?
"Propofol is most often employed during medical procedures to keep patients sedated. It can also be used, however, as a form of therapy for conditions like monitored anesthesia care therapy and sedative therapy."
Are there any historical data sets that we can compare with this Propofol research?
"There are 80 different ongoing clinical trials studying the efficacy of Propofol. 12 of those are large-scale Phase 3 trials. Although the majority of Propofol research is conducted in Jinan, Shandong, there are over 250 other medical facilities running similar studies."
Who else is applying?
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What portion of applicants met pre-screening criteria?
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