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Aminoglycoside Antibiotic

Gentamicin Sulfate for Urinary Tract Infection

Phase 2 & 3

Waitlist Available

Led By Denise Tate, PhD

Research Sponsored by University of Michigan

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

History of traumatic spinal cord injury (SCI) or non-traumatic spinal cord disease, (SCD) with sustained neurological dysfunction

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 6 months

Awards & highlights

Study Summary

This trial looks at whether a medication can help reduce urinary infections and complications in people with spinal cord injuries, as well as improve their quality of life.

Eligible Conditions

Urinary Tract Infection
Spinal Cord Injury
Spinal Cord Disease
Neurogenic Bladder

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

You have a history of spinal cord injury or disease that has caused long-term nerve problems.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 6 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~6 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Number of urinary tract infections (UTI)

Secondary outcome measures

Neurogenic Urinary Bladder

Change in score of Neurogenic Bowel Dysfunction

Trial Design

1Treatment groups

Experimental Treatment

Group I: Gentamicin sulfateExperimental Treatment1 Intervention

Participants initiate Gentamicin instillations every night for a period of 6 months. After baseline and consented they are instructed on how to do the instillations through a catheter, once they receive the drug and aid equipment (i.e. syringes) to do installations. Remaining drug is to be disposed after each use. Participants use their own catheters.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Gentamicin Sulfate

2017

Completed Phase 2

~10

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Department of Health and Human ServicesFED

226 Previous Clinical Trials

928,936 Total Patients Enrolled

University of MichiganLead Sponsor

1,795 Previous Clinical Trials

6,373,923 Total Patients Enrolled

2 Trials studying Urinary Tract Infection

240 Patients Enrolled for Urinary Tract Infection

Denise Tate, PhDPrincipal Investigator - University of Michigan

University of Michigan

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could you please provide a rundown of prior research involving Gentamicin Sulfate?

"There are currently 14 clinical trials registered for Gentamicin Sulfate. Of those, 6 are Phase 3 trials. Most of the Gentamicin Sulfate trials are based in Louisville, Kentucky, but there are a total of 56 locations running trials for the treatment."

Answered by AI

What are some common medical functions of Gentamicin Sulfate?

"Gentamicin Sulfate is most often used to treat ocular inflammation, though it can also help manage corneal infection, communicable diseases, and sycosis barbae."

Answered by AI

Is this trial open to people below the age of eighty?

"This study is welcoming people aged 18 or older but younger than 80."

Answered by AI

What are the entry requirements for participants in this experiment?

"Individuals with spinal cord damage that fall between 18 and 80 years old are the target demographic for this study, of which the investigators are looking to recruit 25."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Gentamicin Bladder Instillations to Prevent Urinary Tract Infections in Patients With Spinal Cord Injury

Denise Tate, PhD 2018. "Gentamicin Bladder Instillations to Prevent Urinary Tract Infections in Patients With Spinal Cord Injury". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03503513.

All > Rsv > Spinal Cord