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Microbiome Restoration Therapy

1 for Clostridium Difficile Infection (MATCH Trial)

Phase 2 & 3
Waitlist Available
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up within 56 days of randomization
Awards & highlights

MATCH Trial Summary

This trial will test whether Fecal Microbiota Therapy (FMT) is better than placebo at preventing C. difficile infection from coming back.

Eligible Conditions
  • Clostridium Difficile (C. diff) Infection

MATCH Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~within 56 days of randomization
This trial's timeline: 3 weeks for screening, Varies for treatment, and within 56 days of randomization for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Possible or Definite Recurrent Clostridium Difficile Infection (CDI), or Death
Secondary outcome measures
Death
Definite Recurrent CDI
Diarrhea That is Negative for C. Difficile by EIA Toxin Test and Polymerase Chain Reaction (PCR)
+9 more
Other outcome measures
Adverse and Serious Adverse Events

MATCH Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: 1Active Control1 Intervention
Fecal Microbiota Therapy (FMT)
Group II: 2Placebo Group1 Intervention
Placebo

Find a Location

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,609 Previous Clinical Trials
3,306,450 Total Patients Enrolled
Aasma Shaukat, MD MPHStudy ChairMinneapolis VA Health Care System, Minneapolis, MN
1 Previous Clinical Trials
50,000 Total Patients Enrolled
Dimitri M Drekonja, MDStudy ChairMinneapolis VA Health Care System, Minneapolis, MN
1 Previous Clinical Trials
273 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there still openings in this experimental treatment program?

"Yes, this information is accurate. The trial is still looking for participants and was last updated 3/3/2022. It was initially posted on 11/15/2018."

Answered by AI
Recent research and studies
clostridioides DifficileJournal
Microbiota or Placebo After Antimicrobial Therapy for Recurrent <i>clostridioides Difficile</i> at Home: A Clinical Trial with Novel Home-based Enrollment
Drekonja, Dimitri M, Aasma Shaukat, Jane H Zhang, Andrew R Reinink, Sean Nugent, Jason A Dominitz, Anne Davis-Karim, Dale N Gerding, and Tassos C Kyriakides. 2021. “Microbiota or Placebo After Antimicrobial Therapy for Recurrent clostridioides Difficile at Home: A Clinical Trial with Novel Home-based Enrollment”. Clinical Trials. SAGE Publications. doi:10.1177/17407745211021198.
clinicaltrials.govStudy
Microbiota or Placebo After Antimicrobial Therapy for Recurrent C. Difficile at Home (MATCH)
2018. "Microbiota or Placebo After Antimicrobial Therapy for Recurrent C. Difficile at Home (MATCH)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03005379.
~24 spots leftby Apr 2025
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