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Antioxidant

Lipoic Acid for Atherosclerosis

Phase 2 & 3

Waitlist Available

Led By Gerd Bobe, PhD

Research Sponsored by Oregon State University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 12 and 24 weeks

Awards & highlights

Study Summary

This trial will test whether R-alpha lipoic acid supplements can help reduce obesity risk factors.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 12 and 24 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~12 and 24 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 and 24 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Triglycerides

Secondary outcome measures

Body weight and composition

Markers of inflammation and oxidative stress

Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: Lipoic AcidActive Control1 Intervention

600 mg R-alpha lipoic acid in morning on empty stomach (two 300 mg capsules)

Group II: PlaceboPlacebo Group1 Intervention

Placebo two caps every morning on empty stomach

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Oregon Health and Science UniversityOTHER

973 Previous Clinical Trials

7,385,712 Total Patients Enrolled

1 Trials studying Atherosclerosis

50 Patients Enrolled for Atherosclerosis

National Center for Complementary and Integrative Health (NCCIH)NIH

832 Previous Clinical Trials

668,833 Total Patients Enrolled

5 Trials studying Atherosclerosis

570 Patients Enrolled for Atherosclerosis

Oregon State UniversityLead Sponsor

49 Previous Clinical Trials

8,281 Total Patients Enrolled

1 Trials studying Atherosclerosis

50 Patients Enrolled for Atherosclerosis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there still open slots available for this research project?

"This particular trial, which was first announced on April 1st 2009, is not currently looking for new patients according to the listing on clinicaltrials.gov. That being said, there are 137 other medical studies that are presently enrolling patients."

Answered by AI

Does this research include octogenarians as test subjects?

"This clinical trial is currently enrolling individuals that are between 18 and 60 years old."

Answered by AI

Might I be able to join the ranks of this research project?

"This trial is looking for 100 patients that have atherogenesis and meet the following age, weight, and other health criteria: -18-60 years old -BMI of 25.0-29.9 kg/m2 or obese (BMI, >30 kg/m2) -Elevated plasma triglycerides (100-400 mg/dl) -Weight stable for the last three months and at lifetime maximum -Exercise limited to 30 minutes 3 times a week or less -Hs-CRP level at baseline of ≤ 10 mg/L"

Answered by AI

Recent research and studies

The Journal of NutritionJournal

A Randomized Controlled Trial of Long-term (r)-α-lipoic Acid Supplementation Promotes Weight Loss in Overweight or Obese Adults Without Altering Baseline Elevated Plasma Triglyceride Concentrations

Bobe, Gerd, Alexander J Michels, Wei-Jian Zhang, Jonathan Q Purnell, Clive Woffendin, Cliff Pereira, Joseph A Vita, et al.. 2020. “A Randomized Controlled Trial of Long-term (r)-α-lipoic Acid Supplementation Promotes Weight Loss in Overweight or Obese Adults Without Altering Baseline Elevated Plasma Triglyceride Concentrations”. The Journal of Nutrition. Oxford University Press (OUP). doi:10.1093/jn/nxaa203.

clinicaltrials.govStudy

Lipoic Acid and Prevention of Heart Disease

Gerd Bobe 2009. "Lipoic Acid and Prevention of Heart Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00765310.

All > Prevention > Heart Disease