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Beta Blocker

Lidocaine for Pain

Phase 2 & 3
Waitlist Available
Led By Michael Norton, MD
Research Sponsored by Wake Forest University Health Sciences
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up following administration of a sub-induction dose of propofol, 0.5 mg/kg up to 50 mg, just prior to full induction
Awards & highlights

Study Summary

This trial tests whether esmolol and lidocaine can relieve propofol injection pain better than a placebo.

Eligible Conditions
  • Pain
  • Injection Site Reaction

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~following administration of a sub-induction dose of propofol, 0.5 mg/kg up to 50 mg, just prior to full induction
This trial's timeline: 3 weeks for screening, Varies for treatment, and following administration of a sub-induction dose of propofol, 0.5 mg/kg up to 50 mg, just prior to full induction for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Pain with propofol injection
Secondary outcome measures
Blood pressure
Heart rate
Oxygen saturation

Trial Design

3Treatment groups
Active Control
Placebo Group
Group I: LidocaineActive Control1 Intervention
1 mg/kg lidocaine to a max of 100 mg
Group II: EsmololActive Control1 Intervention
0.5 mg/kg esmolol to a max of 50 mg
Group III: PlaceboPlacebo Group1 Intervention
Saline water

Find a Location

Who is running the clinical trial?

Wake Forest University Health SciencesLead Sponsor
1,241 Previous Clinical Trials
1,004,204 Total Patients Enrolled
22 Trials studying Pain
2,424 Patients Enrolled for Pain
Michael Norton, MDPrincipal InvestigatorWake Forest University Health Sciences

Media Library

Esmolol (Beta Blocker) Clinical Trial Eligibility Overview. Trial Name: NCT04356352 — Phase 2 & 3
Pain Research Study Groups: Lidocaine, Esmolol, Placebo
Pain Clinical Trial 2023: Esmolol Highlights & Side Effects. Trial Name: NCT04356352 — Phase 2 & 3
Esmolol (Beta Blocker) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04356352 — Phase 2 & 3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people are allowed to participate in this experiment?

"Yes, the clinicaltrials.gov website currently lists this trial as active and recruiting patients. This study was originally posted on September 9th, 2020, with the most recent update being on July 26th, 2022. There is a goal to enroll 150 patients from 1 site."

Answered by AI

What indications does Esmolol usually target?

"Esmolol is an effective medication for patients experiencing cervical syndrome, minor burns, or who have undergone transplant surgery."

Answered by AI

If I wanted to, could I join this clinical trial?

"Investigators are looking for 150 individuals that suffer from pain and meet the age (18-60 years old) and ASA score (1-3) requirements."

Answered by AI

Are there any precedent studies involving Esmolol?

"Esmolol is currently being trialed in 138 active studies, 34 of which are in Phase 3. Most research teams studying Esmolol are based in Calgary, but there are 1112 total facilities running trials for the medication."

Answered by AI

Are new patients still being enrolled in this trial?

"That is accurate. The website clinicaltrials.gov has information indicating that the trial is still looking for participants. This specific trial was first posted on September 9th, 2020 and was edited most recently on July 26th, 2022. There is space for 150 patients at a single site."

Answered by AI

Can elderly individuals participate in this research project?

"The age requirements to participate in this study are between 18 and 60 years old."

Answered by AI

Who else is applying?

What state do they live in?
North Carolina
How old are they?
18 - 65
What site did they apply to?
Wake Forest Health Sciences
What portion of applicants met pre-screening criteria?
Met criteria

How responsive is this trial?

Typically responds via
Email
Most responsive sites:
  1. Wake Forest Health Sciences: < 24 hours
Average response time
  • < 1 Day
Recent research and studies
clinicaltrials.govStudy
Lidocaine, Esmolol, or Placebo to Relieve IV Propofol Pain
2020. "Lidocaine, Esmolol, or Placebo to Relieve IV Propofol Pain". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04356352.
~7 spots leftby Apr 2025
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