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Amino Acid

L-Histidine for HARS Syndrome

Phase 2 & 3
Waitlist Available
Research Sponsored by Lawson Health Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Have molecularly confirmed HARS syndrome (Y454S homozygous).
Capable of giving informed consent or assent, or have an acceptable surrogate capable of giving consent on the participant's behalf.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights

Study Summary

This trial will evaluate whether histidine supplementation can improve symptoms in children with HARS Syndrome.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Auditory ability maintenance or improvement
Changes in severity of acute febrile illness
Visual acuity maintenance or improvement
Secondary outcome measures
Biomarker Changes
Plasma level maintenance

Trial Design

1Treatment groups
Experimental Treatment
Group I: TreatmentExperimental Treatment1 Intervention
L-Histidine in 500mg capsules taken at a dose of 50mg/kg to maintain high-normal serum histidine levels
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
L-Histidine
2018
Completed Phase 1
~20

Find a Location

Who is running the clinical trial?

Lawson Health Research InstituteLead Sponsor
656 Previous Clinical Trials
413,414 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can new patients join this clinical trial?

"According to the listing on clinicaltrials.gov, this study is not recruiting patients at this time. This trial was initially posted on August 1st, 2018 and last updated on June 7th, 2022. There is one other active study that might be of interest."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Histidine Therapy: A Project to Treat HARS Deficiency
2018. "Histidine Therapy: A Project to Treat HARS Deficiency". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02924935.
~2 spots leftby Apr 2025
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