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Florbetapir PET/MR scan for Amyloidosis

Phase 1 & 2
Waitlist Available
Led By Stephen M. Broski, M.D.
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 50-120 minutes post injection
Awards & highlights

Study Summary

This trial will test how well PET/MR works in diagnosing amyloidosis in patients with peripheral nerve damage.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~50-120 minutes post injection
This trial's timeline: 3 weeks for screening, Varies for treatment, and 50-120 minutes post injection for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Locations of peripheral nerve 18-F Florbetapir uptake
Pattern of F-18 Florbetapir uptake (Heterogeneous vs. Homogeneous, focal vs. diffuse)
Secondary outcome measures
Additional sites of 18-F Florbetapir uptake
Morphologic changes
Pattern of contrast enhancement (Solid, heterogeneous or peripheral enhancement)
+1 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Peripheral nerve amyloidosisExperimental Treatment1 Intervention
Patients with pathologically-confirmed peripheral nerve amyloidosis will undergo 18-F Florbetapir PET/MR scan on a GE SIGNA PET/MR scanner.

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,206 Previous Clinical Trials
3,767,075 Total Patients Enrolled
15 Trials studying Amyloidosis
1,956 Patients Enrolled for Amyloidosis
Stephen M. Broski, M.D.Principal InvestigatorMayo Clinic
1 Previous Clinical Trials
24 Total Patients Enrolled
Stephen M BroskiPrincipal InvestigatorMayo Clinic

Media Library

18-F Florbetapir PET/MR scan Clinical Trial Eligibility Overview. Trial Name: NCT03019029 — Phase 1 & 2
Amyloidosis Research Study Groups: Peripheral nerve amyloidosis
Amyloidosis Clinical Trial 2023: 18-F Florbetapir PET/MR scan Highlights & Side Effects. Trial Name: NCT03019029 — Phase 1 & 2
18-F Florbetapir PET/MR scan 2023 Treatment Timeline for Medical Study. Trial Name: NCT03019029 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research endeavor accepting those over the age of forty-five as participants?

"Potential participants must fall in the 18 to 100 years old bracket for this medical trial. There are also 2 trials specifically targeting minors and 97 studies that cater to seniors aged 65 or above."

Answered by AI

Are there any participant slots available in this clinical trial?

"Clinicaltrials.gov shows that this trail, which was initially posted on March 13th 2017 and modified most recently on January 14th 2022, is no longer actively recruiting patients. However, 97 other trials are still accepting new candidates at the present moment."

Answered by AI

Who is eligible to partake in this medical trial?

"This research project requires 10 people aged between 18 and 100 who have been diagnosed with amyloidosis. Candidates must also match the following criteria: Adults of ages ranging from 18 to 100, histologically-verified peripheral nerve amyloidosis or pathogenetically-confirmed non-amyloid sources of peripheral neuropathy."

Answered by AI

What purpose does this medical experiment seek to fulfill?

"This study seeks to measure uptake of 18-F Florbetapir in nerve tissue over a timeframe ranging from 50 minutes to 120 minutes post injection. Secondary objectives include gauging the T1 and T2 characteristics (Hypointense, isointense or hyperintense relative to skeletal muscle), pattern of contrast enhancement (Solid, heterogeneous or peripheral enhancement) and morphological changes (Presence or absence of neural enlargement). All are categorical variables without an associated quantitative scale."

Answered by AI
~1 spots leftby Apr 2025