CLINICAL TRIAL

Opioid disposal education for Agnosia

Recruiting · < 18 · All Sexes · Pittsburgh, PA

Non-Opioid Pain Medications After Intracapsular Adenotonsillectomy

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About the trial for Agnosia

Eligible Conditions
Opioids Use · Agnosia · Analgesia, Postoperative · Adenotonsillectomy

Treatment Groups

This trial involves 3 different treatments. Opioid Disposal Education is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.

Experimental Group 1
Oxycodone
DRUG
+
Acetaminophen
DRUG
+
Ibuprofen
DRUG
+
Opioid disposal education
OTHER
Experimental Group 2
Oxycodone
DRUG
+
Acetaminophen
DRUG
+
Ibuprofen
DRUG
+
Opioid disposal education
OTHER
+
Opioid disposal pouch
OTHER
Control Group 3
Acetaminophen
DRUG
+
Ibuprofen
DRUG

About The Treatment

Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Oxycodone
FDA approved
Acetaminophen
FDA approved
Ibuprofen
FDA approved

Eligibility

This trial is for patients born any sex aged 18 and younger. There is one eligibility criterion to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
• Patients age 3 - 17 undergoing adenotonsillectomy
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: two months post-operatively
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: two months post-operatively.
View detailed reporting requirements
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- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Opioid disposal education will improve 1 primary outcome, 1 secondary outcome, and 12 other outcomes in patients with Agnosia. Measurement will happen over the course of Up until the return of the pain diary within 8 weeks of the surgery.

Use of the opioid disposal pouch
UP UNTIL THE RETURN OF THE PAIN DIARY WITHIN 8 WEEKS OF THE SURGERY
Number of patients who reported that they used the opioid disposal pouch on the last page of the pain diary
Education level
14 DAYS POST-OPERATIVELY
Using the take-home pain diary, parents/guardians of the patients will identify the highest level of education achieved by anyone in the household.
Post-operative nursing phone calls
14 DAYS POST-OPERATIVELY
Number of post-operative phone calls to nursing staff, obtained using the electronic medical record.
Non-opioid group switching to opioid group
14 DAYS POST-OPERATIVELY
Number of non-opioid group members switching to receiving opioid medication - assessed via the take-home pain diary.
Side effects of medications
14 DAYS POST-OPERATIVELY
Number of any of the following side effects experienced: Nausea, vomiting, constipation, stomach ache, difficulty breathing. Assessed at follow-up and take-home pain diary.
Number of readmissions
14 DAYS POST-OPERATIVELY
Number of hospitalizations after discharge in 14 days - assessed using the electronic medical record and the take-home pain diary.
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Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can agnosia be cured?

There are no studies in the literature evaluating the therapeutic role of cognitive rehabilitation for people who are agnisic, and there is very limited evidence of any long term benefit for agnosic patients overall. The lack of controlled trials and the small number of people with agnosia with anosognosia may mean that the results of the current paper have significant limitations.

Anonymous Patient Answer

What are common treatments for agnosia?

There was no evidence that CBT is effective, but there may be an improvement when CBT is paired with training. There is not enough evidence to help with the management of agnosia after the onset of neurological symptoms.

Anonymous Patient Answer

What is agnosia?

The term agnosia is not the commonest term for the perceptual disorder of failing to recognize familiar sights, objects or people and is less associated with a specific lesion than is the term alexia. However, the inability to name or otherwise name objects or concepts is associated with a specific lesion, but that of the hippocampus. A distinction between two separate deficits is suggested: A lexical deficit is characterized by the inability to name familiar objects and people, whilst an object naming deficit is associated with damage to a more anterior inferior frontal region.

Anonymous Patient Answer

What causes agnosia?

The present results support theories favoring an independent origin for agnosia. On the other hand, they fail to support a perceptual account of agnosia that views perception and processing in the parietal lobe as responsible for agnosia.

Anonymous Patient Answer

What are the signs of agnosia?

Lack of visual information about shapes, faces or locations of objects is one of the earliest signs of agnosia following a stroke. Other related signs of agnosia include anosognosia, which is marked by lack of recognition of one's own deficit.\n

Anonymous Patient Answer

How many people get agnosia a year in the United States?

According to the USGS, about 300,000 persons are disabled because of the impairment in memory as a result of aging, traumatic brain injury or brain damage. About 1.2 million persons are also suffering from a permanent, pervasive brain condition (such as Alzheimer's) that causes confusion and mental decline.\n

Anonymous Patient Answer

What is the primary cause of agnosia?

From the limited case study data, the researchers concluded that the primary cause of sensorimotor agnosia is damage to the parietal lobe or primary somatosensory cortex. In addition, it appears that damage to the ventral stream and/or medial pathway may be involved as well. For many patients with sensorimotor agnosia, it may be helpful to consider referral to [Neurologists and Stroke Rehabilitation (NHSR)"(http://www.nice.org.uk/stnhsrac/publications/publications.

Anonymous Patient Answer

What is opioid disposal education?

Recent findings demonstrate that a single classroom intervention improves the perceived education level of students in their use of the disposal of the prescribed opioid; these improvements are apparent after only 12--17 hours of training. Recent findings imply that pharmacists can be used to develop improved education and safety messages on opioids.

Anonymous Patient Answer

What is the latest research for agnosia?

There's a lot of research on how to treat agnosia, and we're just discovering how much more complicated this disease is than we thought earlier. Some things we found that helped us were: good nutrition (diet), stopping good habits, and seeing a doctor for help. We think that these will help the rest of the world to get better treatments for AGNOSIA too\n

Anonymous Patient Answer

Is opioid disposal education safe for people?

Results from a recent paper provides preliminary evidence that opioid DSE programs can be a low risk option for enhancing patient knowledge and confidence with opioids. It is important to acknowledge that a limitation of this study is the small sample size used. Overall the study provides an insight into the benefits of opioid DSE programs. In the future, larger studies are required to evaluate the safety and effectiveness of opioid DSE strategies.

Anonymous Patient Answer

Have there been any new discoveries for treating agnosia?

Agnosia is still a very new and obscure condition. There is still some controversy over the definition of agnosia itself, and whether agnosia was a disorder that should be treated. We need to continue our investigations into the treatment prospects for agnosia. The present study did not demonstrate an improvement in memory for visual stimuli after a [6]fluorene-PET scan with rivitrabine. However, agnosia patients displayed altered regional blood flow in areas involved in visual processing for both visual and auditory stimuli, and in particular their fusiform gyri. Although the results are preliminary, such changes could be induced in the healthy participant by applying [6]fluorene-PET scans.

Anonymous Patient Answer

How does opioid disposal education work?

Knowledge about disposal of opioids was poor in most groups. There is a need to develop more effective approaches to teach this issue in addiction treatment. Further trials with a longer follow-up are needed to investigate the effects of opioid disposal knowledge.

Anonymous Patient Answer
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