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Angiotensin II Receptor Blocker
Losartan for Hamstring Injury
Phase 1 & 2
Waitlist Available
Research Sponsored by James J. Irrgang
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 weeks; 6 months
Awards & highlights
Study Summary
This trial is testing if the drug losartan is safe and effective for treating acute hamstring injuries in adults who participate in high levels of athletics or have a similar work load.
Who is the study for?
Adults over 18 with a recent grade II or III hamstring injury, who are active in sports like football, basketball, soccer, racquet sports, skiing or have physically demanding jobs. Participants must not need surgery for their injury, be non-smokers and not pregnant. They can't take certain blood pressure medicines or have conditions like hypertension.Check my eligibility
What is being tested?
This trial is testing if Losartan (50mg daily) helps adults recover from serious hamstring strains better than a placebo. It's double-blind and randomized: neither doctors nor patients know who gets the real medicine. Patients get an MRI and functional tests before and after the treatment period to measure recovery.See study design
What are the potential side effects?
Losartan may cause dizziness due to low blood pressure, allergic reactions in those sensitive to it, and could interact with other medications affecting blood pressure. The study excludes individuals likely at risk of severe side effects.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 6 weeks; 6 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 weeks; 6 months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Recovery of hamstring muscle function and structure
Recurrence of injury
Reported effects of losartan for hamstring injury for safety and tolerability
+1 moreTrial Design
2Treatment groups
Active Control
Placebo Group
Group I: losartanActive Control1 Intervention
Subjects will taken 50mg of losartan per day for 4 weeks
Group II: placeboPlacebo Group1 Intervention
Subjects will be given placebo to replicate appearance of losartan pills. Placebo pill will be taken once per day.
Find a Location
Who is running the clinical trial?
Wake Forest UniversityOTHER
189 Previous Clinical Trials
164,572 Total Patients Enrolled
James J. IrrgangLead Sponsor
1 Previous Clinical Trials
38 Total Patients Enrolled
Brooke Army Medical CenterFED
118 Previous Clinical Trials
26,516 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You have a severe injury that needs surgery, like a torn ligament that is completely torn or a bone that is fractured.You currently have lower back pain or other related symptoms.You currently smoke cigarettes.You feel lightheaded or dizzy when you stand up, or your blood pressure drops significantly when you stand up.You have diabetes, heart problems, kidney problems, or liver problems.You have had surgery for an aneurysm and it is not safe for you to have an MRI scan.You have metal fragments in your eyes, brain, or spinal cord from things like shrapnel, metal work, or welding.You have a fear of small, enclosed spaces.You have had a moderate or severe hamstring injury in the past week.You have previously injured your hamstring on the same side or have ongoing long-term symptoms.You participate in intense sports like football, basketball, or soccer for more than 100 hours per year. You also engage in activities that involve running and sprinting, like racquet sports, skiing, or physically demanding jobs.
Research Study Groups:
This trial has the following groups:- Group 1: losartan
- Group 2: placebo
Awards:
This trial has 0 awards, including:Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What maladies is losartan usually prescribed to address?
"Losartan is the primary treatment for diabetic nephropathy, and has been seen to effectively tackle left ventricular hypertrophy, proteinuria, and hypertensive disease."
Answered by AI
Are new participants still being admitted to this experiment?
"According to the details presented on clinicaltrials.gov, this trial is currently gathering participants. The initial post was made on July 1st 2016 and updated most recently in January 9th 2022."
Answered by AI
What additional research exists involving losartan?
"As of present, 30 different trials are operating to investigate losartan efficacy. Two have reached Phase 3 and the bulk of these experiments are occurring in San Francisco. Worldwide participation is estimated at 533 separate clinical sites."
Answered by AI
How many individuals have thus far been enrolled in this medical investigation?
"Affirmative. The clinical trial is currently open for enrollment, with the initial posting occurring on July 1st 2016, and a recent update to the listing made on January 9th 2022. 10 patients are needed from one medical facility."
Answered by AI
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