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Dietary Supplement

intervention group for Air Pollution Toxicity (NEAT Trial)

N/A

Waitlist Available

Research Sponsored by University of Louisville

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 months

Awards & highlights

NEAT Trial Summary

This trial will test whether carnosine, a dietary supplement, can protect people from the harmful effects of air pollution.

NEAT Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

endothelial progenitor cells

Secondary outcome measures

arterial stiffness

endothelial microparticles

platelet monocyte aggregates

NEAT Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: intervention groupActive Control1 Intervention

Each participant will be given a daily oral dose of 2 grams of carnosine for 12 weeks

Group II: placebo groupPlacebo Group1 Intervention

Each participant will be given a daily oral dose of 2 grams of placebo for 12 weeks

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of LouisvilleLead Sponsor

338 Previous Clinical Trials

75,685 Total Patients Enrolled

National Institute of Environmental Health Sciences (NIEHS)NIH

284 Previous Clinical Trials

1,232,438 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the age requirement for this clinical trial less than 85 years of age?

"This medical trial is seeking out individuals between the ages of 22 and 65 to participate."

Answered by AI

What is the ceiling on participant enrollment for this clinical trial?

"Affirmative. The information found on clinicaltrials.gov demonstrates that this medical investigation is actively recruiting participants. This trial was initially posted in April 2018 and its latest update happened October 25th of last year, intending to involve 240 patients at one site."

Answered by AI

Are there any particular criteria that make a person an eligible participant in this clinical experiment?

"This clinical trial seeks 240 participants, who must have air pollution toxicity and be within the 22 to 65 year old age range."

Answered by AI

Is this trial still open to participants?

"This clinical trial, which was first publicized on April 1st 2018, is currently recruiting. The study has been updated as recently as October 25th 2022 and further information can be found via clinicaltrials.gov."

Answered by AI

Recent research and studies

Circulation ResearchJournal

Exposure to Fine Particulate Air Pollution Is Associated with Endothelial Injury and Systemic Inflammation

Pope, C. Arden, III, Aruni Bhatnagar, James P. McCracken, Wesley Abplanalp, Daniel J. Conklin, and Timothy O’Toole. 2016. “Exposure to Fine Particulate Air Pollution Is Associated with Endothelial Injury and Systemic Inflammation”. Circulation Research. Ovid Technologies (Wolters Kluwer Health). doi:10.1161/circresaha.116.309279.

Circulation ResearchJournal

Episodic Exposure to Fine Particulate Air Pollution Decreases Circulating Levels of Endothelial Progenitor Cells

O'Toole, Timothy E., Jason Hellmann, Laura Wheat, Petra Haberzettl, Jongmin Lee, Daniel J. Conklin, Aruni Bhatnagar, and C. Arden Pope III. 2010. “Episodic Exposure to Fine Particulate Air Pollution Decreases Circulating Levels of Endothelial Progenitor Cells”. Circulation Research. Ovid Technologies (Wolters Kluwer Health). doi:10.1161/circresaha.110.222679.

Arteriosclerosis, Thrombosis, and Vascular BiologyJournal

Dietary Carnosine Prevents Early Atherosclerotic Lesion Formation in Apolipoprotein E–null Mice

Barski, Oleg A., Zhengzhi Xie, Shahid P. Baba, Srinivas D. Sithu, Abhinav Agarwal, Jian Cai, Aruni Bhatnagar, and Sanjay Srivastava. 2013. “Dietary Carnosine Prevents Early Atherosclerotic Lesion Formation in Apolipoprotein E–null Mice”. Arteriosclerosis, Thrombosis, and Vascular Biology. Ovid Technologies (Wolters Kluwer Health). doi:10.1161/atvbaha.112.300572.

BMJ OpenJournal