Malleo-Lok for Healthy Subjects (HS)

Phase-Based Estimates
1
Effectiveness
1
Safety
University of Iowa, Iowa City, IA
+1 More
Malleo-Lok - Device
Eligibility
18 - 65
All Sexes
Eligible conditions
Healthy Subjects (HS)

Study Summary

This study is evaluating whether a new type of ankle foot orthosis may help improve gait biomechanics and overall joint stiffness.

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Eligible Conditions

  • Healthy Subjects (HS)
  • ALL, Adult

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Malleo-Lok will improve 5 primary outcomes and 6 secondary outcomes in patients with Healthy Subjects (HS). Measurement will happen over the course of Baseline.

Baseline
Ankle Joint Moment
Ankle Joint Power
Ankle Joint Stiffness
Center of Pressure Velocity Magnitude
Center of Pressure Velocity Timing
Modified Socket Comfort Score (Comfort and Smoothness)
Numerical Pain Rating Scale
During Testing
Medial Gastrocnemius Muscle Activity
Peroneus Longus Muscle Activity
Soleus Muscle Activity
Tibialis Anterior Muscle Activity

Trial Safety

Safety Estimate

1 of 3

Trial Design

2 Treatment Groups

No Control Group
CDO-B

This trial requires 20 total participants across 2 different treatment groups

This trial involves 2 different treatments. Malleo-Lok is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

CDO-B
Device
The second brace tested will be labeled CDO-B, this will be either the stiff or the compliant device.
CDO-A
Device
The first brace tested will be labeled CDO-A, this will be either the stiff or the compliant device.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline for reporting.

Who is running the study

Principal Investigator
J. W.
Prof. Jason Wilken, Associate Professor
University of Iowa

Closest Location

University of Iowa - Iowa City, IA

Eligibility Criteria

This trial is for patients born any sex between 18 and 65 years old. There are 5 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Able to perform a full squat without pain
Ability to speak and understand English
Between the ages of 18 and 45
Healthy without current complaint of lower extremity pain, spine pain, open wounds or active infections, or medical or neuromusculoskeletal disorders that have limited their participation in work or exercise in the last 6 months
Able to hop without pain

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can all, adult be cured?

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Because the cure rate for children with ALL is only 5%, the current estimate of cure rate of ALL in the United States is 0.2%. Although this rate is low, many adults in the United States who have ALL have a long and potentially painful remission, which should be the goal of treatment.

Unverified Answer

What are the signs of all, adult?

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As many as two-thirds of a person's symptoms may be non-specific and are therefore unlikely to be cancerous, although they do require further evaluation in the case of suspicion. A full overview may help in the diagnostic evaluation of a complaint; a systematic history of symptoms is particularly important in the case of cancer. The presence of typical symptoms in a medical consultation is also a positive sign of all, adult.

Unverified Answer

What is all, adult?

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Adult patients may be assessed for any condition/disorder/disease and other disorders, provided a clear and thorough history and physical evaluation are available. The history is the primary tool for an accurate clinical assessment of an adult patient, and in some cases supplementary examinations on physical examination are needed. The physical examination includes inspection of the skin, palpation of the abdomen, testing the strength of the heart and lungs, and test of one's reflexes.

Unverified Answer

What causes all, adult?

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Many risk factors are common between both childhood and adult disease, which could explain why adult autoimmune diseases in particular show considerable female predominance. Findings from a recent study has also examined other similarities and differences in presentation between childhood and adult disease.

Unverified Answer

What are common treatments for all, adult?

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The management of adult patients diagnosed with bipolar disorder, major depression, or an anxiety disorder, are similar to those in children. The treatment typically focuses on psychoeducation, coping strategies, mood stabilizers, medication management, and cognitive behavioural therapy.

Unverified Answer

How many people get all, adult a year in the United States?

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The number of adults who develop two or more common chronic diseases such as diabetes, heart disease and chronic obstructive pulmonary disease has increased substantially since the 1980s. Furthermore, the average life span in the US has been increasing steadily for the last three decades. Based on these data, it is possible that the average life span in the United States could be about 7 years less than it was in 1974, but studies are inconclusive.

Unverified Answer

What is the primary cause of all, adult?

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In a recent study, findings highlights the need to improve early and more accurate diagnosis of diabetes mellitus (DM) in India and consequently delay the worsening of DM outcomes. It has been established that the majority of the DM cases have been under treated and untreated by many clinicians in India. The study has found that DM control was better than that in other non-communicable diseases (NCDs) of India as well as in developed countries. However, control, improvement and better management of DM should be given a high priority.

Unverified Answer

What are the latest developments in malleo-lok for therapeutic use?

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As the malleo-lok has gained popularity as a method of drug delivery, it seems that the drug may be used more routinely as an inhalant. It is possible that other malleo-lok will join the current ones in the near future. The recent introduction and development of malleo-lok may result in a significant increase in the number of patients treated with this treatment modality in the near future.

Unverified Answer

What is the latest research for all, adult?

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[In all, adult, research is often overlooked and misunderstood. To help your patients, you need to be up to date on the latest research. In order to help your patients, you can find the latest clinical trials by doing a Powersearch(http://www.powersearch.com/search/research/search.aspx)? using the key words [PTSD, tinnitus, traumatic brain injury, spinal cord injury], or [power] to make sure you are looking through the most up-to-date research that is important to your patients. Go now and discover the latest research for all, adult.

Unverified Answer

Have there been other clinical trials involving malleo-lok?

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This trial is the first study using malleo-lok that shows that malleo-lok can maintain postoperative haemodynamic stability of patients. It is expected that additional studies will confirm our results.

Unverified Answer

What does malleo-lok usually treat?

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Malleo-lok does not use all the medications we tested, but we think it is the first herbal medicine to be found to treat this disease. In any event, malleo-lok looks promising for treating a number of conditions and deserves further studies.

Unverified Answer

How does malleo-lok work?

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The majority of patients used malleo-lok for the treatment of urinary incontinence. There was also evidence that satisfaction and knowledge related to continence improvement were positively associated with female gender. Older patients also reported a positive effect regarding incontinence. The long-term effectiveness of malleo-lok device seems to be limited. Nevertheless, it's used by a small percentage of people and this seems to be a good thing.

Unverified Answer
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