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0.05% Chlorhexidine Gluconate for Periprosthetic Joint Infection

N/A
Waitlist Available
Research Sponsored by University of Southern California
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients presenting to Keck Hospital of USC or USC Verdugo Hills Hospital for primary total knee arthroplasty or total hip arthroplasty.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 90 days
Awards & highlights

Study Summary

This trial will compare the rates of microbial contamination on surgical instruments placed in three different types of surgical splash basins: those filled with sterile water, 3.5% betadine, or 0.05% CHG. The overall purpose of the study is to investigate the efficacy of 0.05% CHG and determine if it is an appropriate solution to use in surgical splash basins for joint replacement surgeries.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~90 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 90 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Microbial Contamination Rate of Surgical Instruments
Secondary outcome measures
90-Day Wound Complication

Trial Design

3Treatment groups
Experimental Treatment
Group I: Sterile WaterExperimental Treatment1 Intervention
Group II: 3.5% betadineExperimental Treatment1 Intervention
Group III: 0.05% chlorhexidine gluconateExperimental Treatment1 Intervention

Find a Location

Who is running the clinical trial?

University of Southern CaliforniaLead Sponsor
906 Previous Clinical Trials
1,596,258 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
OrthopedicsJournal
Is Repetitive Intraoperative Splash Basin Use a Source of Bacterial Contamination in Total Joint Replacement?
Glait, Sergio A., Ran Schwarzkopf, Steven Gould, Joseph Bosco, and James Slover. 2011. “Is Repetitive Intraoperative Splash Basin Use a Source of Bacterial Contamination in Total Joint Replacement?”. Orthopedics. SLACK, Inc.. doi:10.3928/01477447-20110714-06.
Journal of InfectionJournal
Splash Basin Bacterial Contamination During Elective Arthroplasty
ANTO, B, J MCCABE, S KELLY, S MORRIS, L RYNN, and G CORBETTFEENEY. 2006. “Splash Basin Bacterial Contamination During Elective Arthroplasty”. Journal of Infection. Elsevier BV. doi:10.1016/j.jinf.2005.06.013.
Arthroplasty TodayJournal
Intraoperative Chlorhexidine Irrigation to Prevent Infection in Total Hip and Knee Arthroplasty
Frisch, Nicholas B., Omar M. Kadri, Troy Tenbrunsel, Abraham Abdul-Hak, Mossub Qatu, and Jason J. Davis. 2017. “Intraoperative Chlorhexidine Irrigation to Prevent Infection in Total Hip and Knee Arthroplasty”. Arthroplasty Today. Elsevier BV. doi:10.1016/j.artd.2017.03.005.
clinicaltrials.govStudy
Microbial Growth in Operative Splash Basins During Total Joint Arthroplasty
Nathanael Heckmann 2021. "Microbial Growth in Operative Splash Basins During Total Joint Arthroplasty". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04274517.
~7 spots leftby Apr 2025
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