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Behavioural Intervention

Active tDCS for Transcranial Direct Current Stimulation and Memory

N/A
Waitlist Available
Led By David Galllo
Research Sponsored by University of Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up this task lasts approximately 10 minutes and is performed immediately after the episodic memory task (approximately 20 minutes after the end of the tdcs session).
Awards & highlights

Study Summary

This trial will test if electric current to the brain can help improve memory, depending on the time of day.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~this task lasts approximately 10 minutes and is performed immediately after the episodic memory task (approximately 20 minutes after the end of the tdcs session).
This trial's timeline: 3 weeks for screening, Varies for treatment, and this task lasts approximately 10 minutes and is performed immediately after the episodic memory task (approximately 20 minutes after the end of the tdcs session). for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Episodic memory performance
Secondary outcome measures
Working memory performance

Side effects data

From 2012 Phase 3 trial • 60 Patients • NCT01649232
10%
headache
10%
headedness / dizziness
7%
fatigue or nausea
100%
80%
60%
40%
20%
0%
Study treatment Arm
Active tDCS
Controls

Trial Design

5Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: Younger, active tDCS, dlPFCExperimental Treatment1 Intervention
Younger adults (ages 18-30) randomized to this arm will receive 2 sessions of active tDCS stimulation (Soterix Medical) delivered to the left dorsolateral prefrontal cortex. One session will occur in the morning (8 or 9am) and one will occur on a separate day in the afternoon (3 or 4pm).
Group II: Older, active tDCS, dlPFCExperimental Treatment1 Intervention
Older adults (ages 60-75) randomized to this arm will receive 2 sessions of active tDCS stimulation (Soterix Medical) delivered to the left dorsolateral prefrontal cortex. One session will occur in the morning (8 or 9am) and one will occur on a separate day in the afternoon (3 or 4pm). 2.
Group III: Younger, active tDCS, parietal cortexActive Control1 Intervention
Younger adults (ages 18-30) randomized to this arm will receive 2 sessions of active tDCS stimulation (Soterix Medical) delivered to the left parietal cortex (area P5 using the 10-20 EEG system). One session will occur in the morning (8 or 9am) and one will occur on a separate day in the afternoon (3 or 4pm).
Group IV: Older, sham tDCS, dlPFCPlacebo Group1 Intervention
Older adults (ages 60-75) randomized to this arm will receive 2 sessions of sham tDCS stimulation (Soterix Medical) delivered to the left dorsolateral prefrontal cortex. One session will occur in the morning (8 or 9am) and one will occur on a separate day in the afternoon (3 or 4pm).
Group V: Younger, sham tDCS, dlPFC/parietalPlacebo Group1 Intervention
Younger adults (ages 18-30) randomized to this arm will receive 2 sessions of sham tDCS stimulation (Soterix Medical) delivered to either the left dorsolateral prefrontal cortex (area F3 using the 10-20 EEG system, n = 25), or the left parietal cortex (area P5 using the 10-20 EEG system, n = 25). One session will occur in the morning (8 or 9am) and one will occur on a separate day in the afternoon (3 or 4pm).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Active tDCS
2012
Completed Phase 3
~1150

Find a Location

Who is running the clinical trial?

University of ChicagoLead Sponsor
1,003 Previous Clinical Trials
819,478 Total Patients Enrolled
National Institute on Aging (NIA)NIH
1,671 Previous Clinical Trials
28,016,792 Total Patients Enrolled
David GallloPrincipal InvestigatorUniversity of Chicago

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals are the maximum allowed to participate in this clinical investigation?

"Affirmative. According to clinicaltrials.gov, this research initiative is still recruiting patients; it was initially published on March 8th 2019 and last modified June 23rd 2022. 250 individuals are necessary from a single medical centre for the study's completion."

Answered by AI

Could I potentially qualify for this trial's participation?

"This trial is recruitng 250 individuals of sound memory between the ages 18-30 and 60-75. Applicants must demonstrate right handedness, normal or corrected vision, fluency in English (started learning by age 6), comprehension to provide informed consent for study procedures, as well as comply with all protocol requirements. Furthermore, these participants need a score of 23 or higher on the Montreal Cognitive Assessment (corrected according to education) so that we can rule out mild cognitive impairment or dementia per Carson et al's meta analysis from 2018. Lastly, they should also attain an above threshold hit rate 5% greater than false alarm rate when completing our"

Answered by AI

Does this experimental research extend to individuals aged 25 and above?

"Participants in this clinical trial must be between 18 and 75 years of age to meet eligibility criteria."

Answered by AI

Are there vacancies available for individuals to join this trial?

"Affirmative. The information posted on clinicaltrials.gov demonstrates that this experiment is currently seeking participants. It was first uploaded on March 8th 2019 and the details were refreshed as recently as June 23rd 2022, with a goal of enrolling 250 patients at one site."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Effect of Noninvasive Electrical Brain Stimulation on Memory at Different Times of Day in Younger and Older Adults
2019. "Effect of Noninvasive Electrical Brain Stimulation on Memory at Different Times of Day in Younger and Older Adults". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03723850.
~45 spots leftby Apr 2025
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