Ultrasound Imaging for Endometrial Cancer

Recruiting at 6 trial locations

Overseen By Mark Burgess, MD

Age: 18+

Sex: Female

Trial Phase: Academic

Sponsor: Memorial Sloan Kettering Cancer Center

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

10 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

The researchers are doing this study to see how well multiparametric ultrasound (mpUS) imaging can evaluate vaginal tissue before and after IVRT. IVRT is routinely used to treat endometrial cancer but can cause damage to the vaginal tissue (vaginal toxicity). Side effects of vaginal toxicity can include vaginal dryness, itching, soreness, discharge, narrowing or shortening of the vagina (stenosis), and vaginal fibrosis (hardening), which can affect sexual function. The researchers will also look at whether participants are able to complete (tolerate) all mpUS imaging for this study.

Who Is on the Research Team?

Kaled Alektiar, MD

Principal Investigator

Memorial Sloan Kettering Cancer Center

Are You a Good Fit for This Trial?

This study is for individuals with endometrial cancer who are undergoing or have completed Intravaginal Radiation Therapy (IVRT). Participants should be able to undergo multiparametric ultrasound imaging and must not have conditions that interfere with the procedure.

Inclusion Criteria

I have been diagnosed with a specific type of endometrial cancer.

I had surgery for my condition that included removing my uterus, both ovaries, fallopian tubes, and checking my pelvic lymph nodes.

I had surgery to remove my cancer completely, and no visible cancer was left.

What Are the Treatments Tested in This Trial?

Interventions

• Multiparametric Ultrasound Imaging

Trial Overview

The trial is testing how well a type of advanced ultrasound, called multiparametric ultrasound imaging (mpUS), can assess vaginal tissue affected by radiation therapy used in treating endometrial cancer. The goal is to monitor for potential damage from treatment.

How Is the Trial Designed?

Group I: Multiparametric Ultrasound Imaging (mpUS) Experimental Treatment 2 Interventions

All participants in this study will receive standard intravaginal brachytherapy (IVRT) and multiparametric ultrasound (mpUS) imaging right before IVRT, right after the last IVRT, and at 3, 6 and 12 months after IVRT.

Who Is Running the Clinical Trial?

Memorial Sloan Kettering Cancer Center

Lead Sponsor

Trials

1,998

Recruited

602,000+