Genetic Testing for Young Adults with Cancer
(Gen-Y Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial uses a broad genetic test and automated computer systems to identify cancer risk in young adult cancer patients and their close relatives. It aims to catch genetic risks that traditional methods might miss, helping doctors manage these risks more efficiently.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
Is genetic testing for young adults with cancer generally safe?
How is the 66-gene panel treatment for young adult cancers different from other treatments?
The 66-gene panel treatment is unique because it uses a comprehensive genetic testing approach to identify hereditary cancer risks in young adults, allowing for personalized screening and prevention strategies. This differs from traditional single-gene tests by providing a broader analysis of multiple genes, which can lead to more informed and tailored healthcare decisions.34678
What data supports the effectiveness of the treatment 66-gene panel for young adult cancers?
Research shows that multigene panels can be a cost- and time-effective way to test for multiple genes at once, which can help in understanding cancer risk and guiding management options. This approach has been used effectively in hereditary breast and ovarian cancer to estimate risk and inform treatment decisions.49101112
Who Is on the Research Team?
Katherine L Nathanson, MD
Principal Investigator
University of Pennsylvania
Steven Joffe, MD
Principal Investigator
University of Pennsylvania
Are You a Good Fit for This Trial?
This trial is for young adults aged 18-39, diagnosed with a solid tumor cancer within the last year and have visited Penn Medicine at least twice. It's not for those who already know they have a genetic predisposition to cancer, have certain types of thyroid or in situ cancers, leukemia, or had previous genetic testing after their diagnosis.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Enrollment and Randomization
Consenting patients are randomized into study arms and complete initial surveys
Genetic Testing
Participants undergo genetic testing using a broad cancer risk gene panel
Follow-up
Participants are monitored for adherence to risk reduction interventions and genetic risk ascertainment
What Are the Treatments Tested in This Trial?
Interventions
- 66-gene panel for young adult cancers
- Broad gene panel for young adult cancers
- Standard
66-gene panel for young adult cancers is already approved in United States, European Union, Canada for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Pennsylvania
Lead Sponsor