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Antibiotic

Vancomycin for Hand Injuries and Disorders

Phase 1
Waitlist Available
Led By Kevin Renfree, MD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

Study Summary

This trial is testing if a lower dose of antibiotics given directly to the site of infection is more effective than the standard IV dose.

Eligible Conditions
  • Hand Injuries and Disorders
  • Wrist Injury
  • Hand Injuries
  • Infections
  • Osteoarthritis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Tissue concentrations of vancomycin
Secondary outcome measures
Adverse Events

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Bier Block GroupExperimental Treatment2 Interventions
Subjects will receive antibiotic Vancomycin from a Bier Block (injected into an arm vein with a tourniquet up to keep antibiotics in the arm). Samples will be collected from bone and tissue that is normally removed during surgery.
Group II: Systemic Intravenous IV GroupActive Control1 Intervention
Subjects will receive antibiotic Vancomycin through intravenous administration. Samples will be collected from bone and tissue that is normally removed during during surgery.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Bier Block
2021
Completed Phase 1
~20
Vancomycin
FDA approved

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,210 Previous Clinical Trials
3,766,953 Total Patients Enrolled
Kevin Renfree, MDPrincipal InvestigatorMayo Clinic
1 Previous Clinical Trials

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Vancomycin Tissue Concentrations by Bier Block or Intravenous Administration
Kevin J. Renfree 2021. "Vancomycin Tissue Concentrations by Bier Block or Intravenous Administration". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04673877.
~6 spots leftby Apr 2025
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