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Inorganic Nitrate Supplement

Acute Moderate-Intensity Exercise for Vasodilation

Phase 1
Waitlist Available
Led By Arthur Weltman, PhD
Research Sponsored by University of Virginia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 180 minutes post-baseline.
Awards & highlights

Study Summary

This trial looks at whether post-menopausal women who take nitrates have better cardiovascular health than those who don't.

Eligible Conditions
  • Vasodilation
  • Arterial Stiffness

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~180 minutes post-baseline.
This trial's timeline: 3 weeks for screening, Varies for treatment, and 180 minutes post-baseline. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Baseline Flow-Mediated Dilation
Post-Exercise/Control Flow-Mediated Dilation (120 minutes)
Post-Exercise/Control Flow-Mediated Dilation (150 min)
+3 more
Secondary outcome measures
Baseline Pulse Wave Velocity
Post-Exercise/Control Pulse Wave Velocity (120 min)
Post-Exercise/Control Pulse Wave Velocity (150 min)
+3 more

Trial Design

3Treatment groups
Active Control
Placebo Group
Group I: Acute Moderate-Intensity ExerciseActive Control2 Interventions
Subjects will exercise at an intensity at the lactate threshold until 200 kcal are expended. Pre- and post-testing measures of vascular health will be completed at baseline (0 min) and again 60, 90, 120, 150, 180 min post-baseline testing, with exercise taking place during time points 0-60 min.
Group II: Acute High-Intensity ExerciseActive Control2 Interventions
Subjects will exercise at an intensity of 75% of the difference between the lactate threshold and VO2peak until 200 kcal are expended. Pre- and post-testing measures of vascular health will be completed at baseline (0 min) and again 60, 90, 120, 150, 180 min post-baseline testing, with exercise taking place during time points 0-60 min.
Group III: Non-Exercise ControlPlacebo Group2 Interventions
Measures of vascular health will be completed at baseline (0 min) and again 60, 90, 120, 150, 180 min post-baseline testing, without exercise taking place during time points 0-60 min.

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

University of VirginiaLead Sponsor
753 Previous Clinical Trials
1,245,007 Total Patients Enrolled
Arthur Weltman, PhDPrincipal InvestigatorProfessor of Kinesiology
1 Previous Clinical Trials
165 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any regulatory endorsements for Acute High-Intensity Exercise?

"Our team at Power has given Acute High-Intensity Exercise a rating of 1, meaning there is limited evidence supporting its safety and efficacy due to it being in the first phase of clinical trials."

Answered by AI

What criteria must potential participants meet to be included in this trial?

"Prospective participants should be between the ages of 45 and 75, possess vasodilation, and must satisfy additional inclusion criteria. This study is searching for around 30 individuals to join their ranks."

Answered by AI

In what ways could this experiment result in beneficial outcomes?

"This 180 minute clinical trial assesses the efficacy of Post-Exercise/Control Flow-Mediated Dilation. Secondary goals are to measure Pulse Wave Velocity at 60, 90, and 150 minutes post baseline using SphygmoCor Xcel equipment."

Answered by AI

Is this research study still accepting participants?

"Per the information on clinicaltrials.gov, this experiment is actively recruiting participants and has been since it was posted in November 2021 with an update in January 2022."

Answered by AI

Does this trial have an age limit, and if so, does it extend to seniors?

"This clinical research program is open to individuals aged 45 or above, but not exceeding 75 years."

Answered by AI

How many people have agreed to participate in this experiment?

"Affirmative. According to the info on clinicaltrials.gov, this clinical trial is actively recruiting participants since its inception in November 2021 and last updated at the end of January 2022. The study requires 30 patients from a single site for enrollment."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Effects of Inorganic Nitrate and Intensity of Exercise on Cardiovascular Health in Post-Menopausal Females
Arthur L Weltman 2021. "Effects of Inorganic Nitrate and Intensity of Exercise on Cardiovascular Health in Post-Menopausal Females". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05221905.
~7 spots leftby Apr 2025
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