Acute High-Intensity Exercise for Vasodilation

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Vasodilation+1 MoreBEET IT - Concentrate Beet root juice (nitrate depleted) - Drug
Eligibility
45 - 75
Female
What conditions do you have?
Select

Study Summary

This trial looks at whether post-menopausal women who take nitrates have better cardiovascular health than those who don't.

Eligible Conditions
  • Arterial Stiffness
  • Vasodilation

Treatment Effectiveness

Study Objectives

6 Primary · 6 Secondary · Reporting Duration: 180 minutes post-baseline.

120 minutes post-baseline.
Post-Exercise/Control Flow-Mediated Dilation (120 minutes)
Post-Exercise/Control Pulse Wave Velocity (120 min)
150 minutes post-baseline.
Post-Exercise/Control Flow-Mediated Dilation (150 min)
Post-Exercise/Control Pulse Wave Velocity (150 min)
180 minutes post-baseline.
Post-Exercise/Control Flow-Mediated Dilation (180 min)
Post-Exercise/Control Pulse Wave Velocity (180 min)
60 minutes post-baseline.
Post-Exercise/Control Flow-Mediated Dilation (60 minutes)
Post-Exercise/Control Pulse Wave Velocity (60 min)
90 minutes post-baseline.
Post-Exercise/Control Flow-Mediated Dilation (90 minutes)
Post-Exercise/Control Pulse Wave Velocity (90 min)
Baseline (minute 0).
Baseline Flow-Mediated Dilation
Baseline Pulse Wave Velocity

Trial Safety

Trial Design

3 Treatment Groups

Acute High-Intensity Exercise
1 of 3
Acute Moderate-Intensity Exercise
1 of 3
Non-Exercise Control
1 of 3

Active Control

Non-Treatment Group

30 Total Participants · 3 Treatment Groups

Primary Treatment: Acute High-Intensity Exercise · Has Placebo Group · Phase 1

Acute High-Intensity ExerciseActiveComparator Group · 2 Interventions: BEET IT - Concentrate Beet root juice (nitrate depleted), BEET IT - Concentrate Beet root juice · Intervention Types: Drug, Drug
Acute Moderate-Intensity ExerciseActiveComparator Group · 2 Interventions: BEET IT - Concentrate Beet root juice (nitrate depleted), BEET IT - Concentrate Beet root juice · Intervention Types: Drug, Drug
Non-Exercise ControlPlaceboComparator Group · 2 Interventions: BEET IT - Concentrate Beet root juice (nitrate depleted), BEET IT - Concentrate Beet root juice · Intervention Types: Drug, Drug

Trial Logistics

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 180 minutes post-baseline.

Who is running the clinical trial?

University of VirginiaLead Sponsor
687 Previous Clinical Trials
1,464,240 Total Patients Enrolled

Eligibility Criteria

Age 45 - 75 · Female Participants · 4 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You are post-menopausal, meaning you have not had a menstrual cycle for at least 1 year.