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Bile Acid

TUDCA for Ulcerative Colitis (TUDCA Trial)

Phase 1
Waitlist Available
Research Sponsored by Washington University School of Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up every 2 weeks after starting tudca until 2 weeks after completing 6 weeks of tudca treatment. (i.e. study points weeks 2, 4, 6 and 8)
Awards & highlights

TUDCA Trial Summary

This trial is testing a new ulcerative colitis treatment to see if it is safe and effective.

Eligible Conditions
  • Ulcerative Colitis

TUDCA Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~every 2 weeks after starting tudca until 2 weeks after completing 6 weeks of tudca treatment. (i.e. study points weeks 2, 4, 6 and 8)
This trial's timeline: 3 weeks for screening, Varies for treatment, and every 2 weeks after starting tudca until 2 weeks after completing 6 weeks of tudca treatment. (i.e. study points weeks 2, 4, 6 and 8) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Determine the effect of TUDCA treatment on ER stress in colon biopsy tissues from subjects with symptomatic ulcerative colitis
Secondary outcome measures
Change in inflammation on histology by Goebes index
Change ulcerative colitis disease activity based on Total Mayo Score
Monitoring of UC patients for TUDCA safety and tolerability: Adverse events

TUDCA Trial Design

1Treatment groups
Experimental Treatment
Group I: TUDCAExperimental Treatment1 Intervention
1.75-2 grams daily in divided dosing

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Washington University School of MedicineLead Sponsor
1,931 Previous Clinical Trials
2,299,696 Total Patients Enrolled
Crohn's and Colitis FoundationOTHER
43 Previous Clinical Trials
27,884 Total Patients Enrolled
16 Trials studying Ulcerative Colitis
12,714 Patients Enrolled for Ulcerative Colitis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
TUDCA as a Therapy for Ulcerative Colitis (UC)
2019. "TUDCA as a Therapy for Ulcerative Colitis (UC)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04114292.
All > Ulcerative Colitis > Colitis
~2 spots leftby Apr 2025
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