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Hormone Therapy

Hypothyroidism QOL questionnaire for Thyroid Cancer

Phase 1
Waitlist Available
Led By Stephanie Fish, MD
Research Sponsored by Memorial Sloan Kettering Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 5
Awards & highlights

Study Summary

This trial will test whether long-term, high-dose thyroid hormone therapy causes patients to develop resistance to the treatment.

Eligible Conditions
  • Thyroid Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 5
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 5 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
change in peak TSH levels

Trial Design

2Treatment groups
Experimental Treatment
Group I: Patients with no history of TSH suppressionExperimental Treatment3 Interventions
Study subjects will be given 200mcg of TRH as a single intravenous (IV) bolus in endocrine clinic on Day 1 and Day 5. LT3 will be administered orally, twice a day (12 hours apart i.e. 8 AM and 8 PM) at a dosage of 10 mcg on Day 2-4. Levothyroxine will be taken after the TRH stimulation tests on Day 1 and day 5. Levothyroxine will be taken on Days 2-4 of the study. *Patients will take their own LT4 that they are prescribed by their endocrinologist. The dose of Levothyroxine is titrated for each patient.
Group II: Patients with a history of thyroid hormone suppression (TSH<0.5 mU/L) for at least 5 yearsExperimental Treatment3 Interventions
Study subjects will be given 200mcg of TRH as a single intravenous (IV) bolus in endocrine clinic on Day 1 and Day 5. LT3 will be administered orally, twice a day (12 hours apart i.e. 8 AM and 8 PM) at a dosage of 10 mcg on Day 2-4. Levothyroxine will be taken after the TRH stimulation tests on Day 1 and day 5. Levothyroxine will be taken on Days 2-4 of the study. *Patients will take their own LT4 that they are prescribed by their endocrinologist. The dose of Levothyroxine is titrated for each patient.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Levothyroxine
FDA approved

Find a Location

Who is running the clinical trial?

Memorial Sloan Kettering Cancer CenterLead Sponsor
1,933 Previous Clinical Trials
585,620 Total Patients Enrolled
Stephanie Fish, MDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are patients being actively recruited for this research project?

"Indeed, the clinicaltrials.gov website contains information that this trial is currently enrolling patients. The listing for this study was created on April 27th, 2021 and updated most recently on August 12th, 2022. Presently, the researchers are looking to enroll 16 more patients from a single site."

Answered by AI

How many people are eligible to participate in this research?

"The latest information from clinicaltrials.gov suggests that this trial is still recruiting patients. The posting for the trial went up on April 27th, 2021 and was updated as recently as August 12th, 2022. So far, 16 people have been enrolled at 1 location."

Answered by AI

Does the Hypothyroidism QOL questionnaire carry any risks for patients?

"Because a Phase 1 trial only provides limited data regarding safety and efficacy, our team has estimated the Hypothyroidism QOL questionnaire to be a 1 on our scale."

Answered by AI

Why do doctors often ask patients to take the Hypothyroidism QOL questionnaire?

"The Hypothyroidism QOL questionnaire can be used by medical professionals to treat patients with malignant neoplasms, euthyroid goitre, and adiposity."

Answered by AI

Who else is applying?

What state do they live in?
New Jersey
How old are they?
18 - 65
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Study of Resistance to Thyroid Hormone After Long-term Exposure in People With Thyroid Cancer
2021. "Study of Resistance to Thyroid Hormone After Long-term Exposure in People With Thyroid Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04868045.
~0 spots leftby Apr 2025
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