VP-001 for Retinal Dystrophy
(Platypus Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new eye injection treatment called VP-001 for people with a genetic condition that affects their vision. The goal is to see if it is safe and can help the damaged cells in their eyes.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. However, you cannot have used anti-VEGF agents within 2 months or corticosteroid injections within the last 3 months before starting the trial.
Is VP-001 (valproic acid) safe for humans?
How is the drug VP-001 different from other treatments for retinal dystrophy?
VP-001, also known as valproic acid, is unique because it is being explored for its potential to treat retinal dystrophy, specifically retinitis pigmentosa, by possibly affecting visual function. Unlike other treatments, it is administered orally and has been studied for its long-term safety and efficacy in this condition.12346
What data supports the effectiveness of the drug VP-001 for Retinal Dystrophy?
Who Is on the Research Team?
Sreenivasu Mudumba
Principal Investigator
PYC
Are You a Good Fit for This Trial?
Adults with a genetic diagnosis of PRPF31 mutation-associated retinal dystrophy (RP11) can join this trial. They must be willing to follow the study plan and attend all visits, use effective birth control if they can have children, and not be pregnant or breastfeeding. People with uncontrolled diseases, recent certain eye treatments or surgeries, other gene therapy for retinal conditions, or excessive drug/alcohol use cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive intravitreal administration of VP-001 in a dose escalation manner to evaluate safety and tolerability
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- VP-001
Find a Clinic Near You
Who Is Running the Clinical Trial?
PYC Therapeutics
Lead Sponsor