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Carbapenem Antibiotic

Tebipenem tablet form for Relative Bioavailability

Phase 1
Waitlist Available
Research Sponsored by Hartford Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 8 hours
Awards & highlights

Study Summary

This trial is testing how well the antibiotic tebipenem works when given through a feeding tube, with or without tube feeds.

Eligible Conditions
  • Relative Bioavailability

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~8 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Tebipenem drug exposure

Trial Design

3Treatment groups
Experimental Treatment
Group I: Whole Tebipenem TabletExperimental Treatment1 Intervention
Tebipenem tablet will be swallowed whole without crushing.
Group II: Crushed Tebipenem Tablet without Tube feedsExperimental Treatment2 Interventions
Crushed tebipenem tablets will be administered by syringe through the nasogastric tube and flushed with water to ensure all drug is passed through.
Group III: Crushed Tebipenem Tablet with Tube feedsExperimental Treatment2 Interventions
Crushed tebipenem tablets will be administered by syringe through the nasogastric tube and flushed with water to ensure all drug is passed through. Subjects will also receive concurrent enteral tube feeds (feeds run for 2h before dose and 4h post-dose).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Tebipenem tablet form
2022
Completed Phase 1
~20

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Spero TherapeuticsIndustry Sponsor
22 Previous Clinical Trials
4,824 Total Patients Enrolled
Hartford HospitalLead Sponsor
133 Previous Clinical Trials
18,920 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Bioavailability of Tebipenem (SPR994) Crushed Tablet
2022. "Bioavailability of Tebipenem (SPR994) Crushed Tablet". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05296382.
~4 spots leftby Apr 2025
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