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Cancer Vaccine
Poly-ICLC (Cohort B) for Prostate Cancer (PORTER Trial)
Phase 1
Waitlist Available
Research Sponsored by Parker Institute for Cancer Immunotherapy
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Provide fresh pre-treatment core needle or incisional biopsy of a metastatic tumor lesion not previously irradiated. Fine needle aspiration is not acceptable.
Additionally, if a pre-treatment biopsy is not medically feasible for participants with bone only disease, formalin-fixed paraffin-embedded (FFPE) tumor specimen in a paraffin block (preferred) or at least 10 slides containing unstained, freshly cut, serial sections must be provided.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 2.5 years
Awards & highlights
PORTER Trial Summary
This trial will look at different combinations of immunotherapy to see if they are safe and effective in treating prostate cancer that has spread and is resistant to hormone therapy.
Eligible Conditions
- Prostate Cancer
PORTER Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowPORTER Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 2.5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 2.5 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Incidence and severity of adverse events
Secondary outcome measures
Disease control rate
Objective response rate (ORR)
Overall survival (OS)
+2 morePORTER Trial Design
3Treatment groups
Experimental Treatment
Group I: Cohort C: CDX-301 + INO-5151 + NivolumabExperimental Treatment4 Interventions
Group II: Cohort B: SBRT + CDX-301 + Poly-ICLC + NivolumabExperimental Treatment4 Interventions
Group III: Cohort A: NKTR-214 + NivolumabExperimental Treatment2 Interventions
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cellectra 2000
2019
Completed Phase 1
~50
CDX-301 (Cohort B and C)
2019
Completed Phase 1
~50
Poly-ICLC (Cohort B)
2019
Completed Phase 1
~50
Stereotactic body radiation therapy (SBRT) (Cohort B)
2019
Completed Phase 1
~50
INO-5151 (Cohort C)
2019
Completed Phase 1
~50
Nivolumab (Cohort A, B and C)
2019
Completed Phase 1
~50
NKTR-214 (Cohort A)
2019
Completed Phase 1
~50
Find a Location
Who is running the clinical trial?
Bristol-Myers SquibbIndustry Sponsor
2,629 Previous Clinical Trials
4,126,273 Total Patients Enrolled
42 Trials studying Prostate Cancer
5,447 Patients Enrolled for Prostate Cancer
Celldex TherapeuticsIndustry Sponsor
60 Previous Clinical Trials
3,801 Total Patients Enrolled
1 Trials studying Prostate Cancer
2 Patients Enrolled for Prostate Cancer
Cancer Research Institute, New York CityOTHER
20 Previous Clinical Trials
1,256 Total Patients Enrolled
1 Trials studying Prostate Cancer
58 Patients Enrolled for Prostate Cancer
Frequently Asked Questions
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