← Back to Search

anti-PSMA monoclonal antibody MDX1201-A488 for Prostate Cancer

Phase 1
Waitlist Available
Led By Ali Zhumkhawala, MD
Research Sponsored by City of Hope Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 1 year
Awards & highlights

Study Summary

This trial is testing an antibody that could help surgeons better see prostate tumors during surgery.

Eligible Conditions
  • Prostate Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Imaging ability of anti-PMSA monoclonal antibody MDX1201-A488

Trial Design

1Treatment groups
Experimental Treatment
Group I: Diagnostic (MDX1201-A488, IOOI, RALP)Experimental Treatment6 Interventions
Patients receive anti-PSMA monoclonal antibody MDX1201-A488 IV over 30 minutes on day 1 and undergo IOOI during RALP on day 3.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
anti-PSMA monoclonal antibody MDX1201-A488
2015
Completed Phase 1
~10
robot-assisted laparoscopic surgery
2012
Completed Phase 3
~230

Find a Location

Who is running the clinical trial?

National Cancer Institute (NCI)NIH
13,664 Previous Clinical Trials
40,925,998 Total Patients Enrolled
561 Trials studying Prostate Cancer
507,095 Patients Enrolled for Prostate Cancer
City of Hope Medical CenterLead Sponsor
565 Previous Clinical Trials
1,921,453 Total Patients Enrolled
14 Trials studying Prostate Cancer
5,613 Patients Enrolled for Prostate Cancer
Ali Zhumkhawala, MDPrincipal InvestigatorCity of Hope Medical Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the trial recruiting elderly individuals as participants?

"This clinical trial is open to patients aged 36-74. For the population younger than 18, there are 73 studies and for those over 65, 1254 studies can be found."

Answered by AI

What potential hazards are associated with participating in a pharmacological study?

"As this is early stage research, the hazard rating for this pharmacological study was assessed as a 1 due to limited evidence of safety and efficacy."

Answered by AI

Under what conditions can individuals engage in this clinical trial?

"This trial is enrolling 20 patients with stage iv prostate cancer that are between 36 and 74 years of age. In order to qualify, the following conditions must be met: ECOG performance status; men agreeing to contraceptive use for 6 months after the duration of study participation; confirmed adenocarcinoma diagnosis without small cell, neuroendocrine or transitional cases; life expectancy above 10 years determined by physician; PSA level >10 ng/ml ; Gleason score >=7 ; Clinical stage>=T2c; bone scan not showing skeletal metastases (x-ray film or MRI tests may be done if results unclear); 3"

Answered by AI

Is this trial still accepting new participants?

"With reference to the clinicaltrials.gov website, it appears that this experiment is not currently recruiting participants. This trial was originally posted on March 5th 2015 and last refreshed on March 17th 2022. Nevertheless, there are 1259 other studies actively seeking volunteers at present."

Answered by AI
~1 spots leftby Apr 2025