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Cofactor

Tetrahydrobiopterin for Chronic Obstructive Pulmonary Disease

Phase 1
Waitlist Available
Research Sponsored by University of Massachusetts, Amherst
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 hours
Awards & highlights

Study Summary

This trial looks at how well a treatment works in people with COPD who also have skeletal muscle dysfunction.

Eligible Conditions
  • Chronic Obstructive Pulmonary Disease
  • Tetrahydrobiopterin Deficiency
  • Stress Oxidative

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Mitochondrial function
intracellular PO2
Secondary outcome measures
Peripheral Blood flow
systemic blood markers of oxidative stress

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: acute BH4/Tetrahydrobiopterin treatmentExperimental Treatment1 Intervention
Oral supplement, Pill, 10 mg/kg of body weight
Group II: PlaceboPlacebo Group1 Intervention
Oral supplement, Pill, Placebo pill with inert excipient
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Sapropterin
FDA approved

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

University of Massachusetts, AmherstLead Sponsor
78 Previous Clinical Trials
467,772 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
O2 Transport and Utilization in Health and Lung Disease
2021. "O2 Transport and Utilization in Health and Lung Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04014712.
~0 spots leftby Apr 2025
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