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Dopamine Agonist

Pramipexole for Parkinson's Disease

Phase 1
Waitlist Available
Led By Richard R Darby, M.D.
Research Sponsored by Vanderbilt University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up two weeks
Awards & highlights

Study Summary

This trial is investigating if dopamine agonists, a type of medication used to treat Parkinson's Disease, cause social problems by altering social decision-making.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~two weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and two weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
The change in a harm aversion cognitive moral decision-making task
change in blood flow in the ventral striatum per ASL images

Side effects data

From 2017 Phase 4 trial • 52 Patients • NCT02033369
82%
nausea
59%
headache
50%
somnolence
45%
Lightheadedness
45%
Dry Mouth
41%
Insomnia
41%
Restlessness
36%
Dizziness
32%
Forgetfulness
32%
Vomiting
32%
Heartburn
32%
decreased libido
27%
Blurry Vision
27%
Decreased Appetite
27%
Increased Appetite
23%
Diarrhea
23%
Sleep Attacks
23%
Skin Problems
18%
Constipation
18%
Sweating
18%
Impaired Coordination
14%
Sexual Dysfunction
14%
compulsive behaviorws
9%
Bruising
9%
tremor
9%
Impaired Concentration
9%
fatigue
100%
80%
60%
40%
20%
0%
Study treatment Arm
MDD Patients

Trial Design

4Treatment groups
Experimental Treatment
Group I: Non-impulsive, pramipexole then placeboExperimental Treatment2 Interventions
half of the non-impulsive group will first get the pramipexole on the first day and the placebo on the second day
Group II: Non-impulsive group, placebo then pramipexoleExperimental Treatment2 Interventions
half of the non-impulsive group will first get the placebo on the first day and the pramipexole on the second day
Group III: Impulsive group, pramipexole then placeboExperimental Treatment2 Interventions
half of the impulsive group will first get the pramipexole on the first day and the placebo on the second day
Group IV: Impulsive group, placebo then pramipexoleExperimental Treatment2 Interventions
half of the impulsive group will first get the placebo on the first day and pramipexole on the second day
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Pramipexole
2008
Completed Phase 4
~11170
Placebo
1995
Completed Phase 3
~2670

Find a Location

Who is running the clinical trial?

United States Department of DefenseFED
865 Previous Clinical Trials
327,681 Total Patients Enrolled
Vanderbilt University Medical CenterLead Sponsor
859 Previous Clinical Trials
672,349 Total Patients Enrolled
Richard R Darby, M.D.Principal InvestigatorVanderbilt University Medical Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could you elucidate the other research endeavors that have utilized Pramipexole?

"Presently, there are 3 trials that explore Pramipexole and one of them is currently in the final stage. Most of these experiments take place in Bhubaneswar, Orissa yet 4 other locations likewise offer this prescription to trial participants."

Answered by AI

How many participants are registering for this research initiative?

"Affirmative. The clinicaltrials.gov website confirms that, having been initially listed on December 3rd 2019, this medical trial is presently recruiting volunteers. 60 participants are sought from a single location."

Answered by AI

Has Pramipexole been given clearance by the Food and Drug Administration?

"With limited data supporting Pramipexole's efficacy and safety, our team at Power assessed it with a score of 1."

Answered by AI

Is enrollment still available for the clinical experiment?

"Affirmative. According to clinicaltrials.gov, this experiment is recruiting participants as we speak; it was initially posted on December 3rd 2019 and last edited May 2nd 2022. 60 individuals are being sought at a single medical site."

Answered by AI

Is my candidacy for this experiment being considered?

"This medical trial has a criteria for acceptance which includes having Parkinson disease and being aged between 45-80. It is seeking to recruit 60 volunteers in total."

Answered by AI

Does this experiment have an age requirement, and can minors participate?

"This medical experiment is inviting individuals aged 45 and above, but below 80 years old."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Social Decision Making in Parkinson's Disease
Richard Darby 2019. "Social Decision Making in Parkinson's Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04249544.
~3 spots leftby May 2025
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