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Local Anesthetic

Lidocaine for Pain Management (NeuCLA Trial)

Phase 1
Waitlist Available
Led By Keith M Vogt, MD, PhD
Research Sponsored by Keith M. Vogt, MD, PhD
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4.5 minutes
Awards & highlights

NeuCLA Trial Summary

This trial will study how lidocaine affects pain processing and cognitive function by looking at brain activity.

Who is the study for?
This trial is for healthy adults aged 18 to 70 with normal body weight. Participants must have a valid email and phone number, not be pregnant, have no metal implants or severe tattoos, no history of seizures or heart rhythm problems, not claustrophobic, and not on certain medications like antiepileptics or antidepressants.Check my eligibility
What is being tested?
The study tests how intravenous lidocaine affects pain processing and cognitive function using brain imaging (fMRI). It's a short-term study with one visit and focuses on the changes in brain activity related to pain relief provided by lidocaine.See study design
What are the potential side effects?
Potential side effects from IV lidocaine may include allergic reactions if sensitive to local anesthetics of the amide type, issues due to pre-existing liver or kidney dysfunction, risk of methemoglobinemia especially in those with G6PD deficiency.

NeuCLA Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4.5 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4.5 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Brain
Resting-state functional connectivity difference: drug-free minus lidocaine
Secondary outcome measures
Lidocaine
Motor response times
Lidocaine

NeuCLA Trial Design

1Treatment groups
Experimental Treatment
Group I: LidocaineExperimental Treatment2 Interventions
Subjects will receive lidocaine during the drug portion of the experiment.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Lidocaine IV
2020
Completed Phase 4
~450
Peripheral Nerve Stimulation
2016
Completed Phase 1
~1380

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Keith M. Vogt, MD, PhDLead Sponsor
3 Previous Clinical Trials
220 Total Patients Enrolled
2 Trials studying Pain
210 Patients Enrolled for Pain
National Institute of General Medical Sciences (NIGMS)NIH
268 Previous Clinical Trials
248,730 Total Patients Enrolled
8 Trials studying Pain
825 Patients Enrolled for Pain
Keith M Vogt, MD, PhDPrincipal InvestigatorUniversity of Pittsburgh
3 Previous Clinical Trials
242 Total Patients Enrolled
3 Trials studying Pain
242 Patients Enrolled for Pain

Media Library

Lidocaine IV (Local Anesthetic) Clinical Trial Eligibility Overview. Trial Name: NCT05501600 — Phase 1
Pain Research Study Groups: Lidocaine
Pain Clinical Trial 2023: Lidocaine IV Highlights & Side Effects. Trial Name: NCT05501600 — Phase 1
Lidocaine IV (Local Anesthetic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05501600 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research trial have an age restriction?

"In compliance with the parameters of this clinical trial, all participants must be at least 18 years old and no older than 70."

Answered by AI

How many individuals are being enrolled into the experiment?

"Yes, according to the clinicaltrials.gov information, this medical trial is currently recruiting participants. It was initially posted on November 22nd 2022 and updated lastly a week later on November 28th of that same year. The investigators are looking for 30 patients from one site to enrol in the study."

Answered by AI

Are there any vacancies left for participants in this research project?

"According to the clinicaltrials.gov, this experiment is actively searching for participants with a posting date of November 22nd 2022 and last edited on November 28th 2022."

Answered by AI

Who is eligible to partake in this medical research?

"This trial has a limited enrolment of 30, and is seeking adults aged between 18 and 70 who are suffering from pain. Additionally, these individuals must have an average body weight, be in good general health, and lack any specified conditions."

Answered by AI

What is the intended outcome of this clinical experiment?

"This 4.5 minute trial intends to detect variances in resting-state functional connectivity when comparing drug-free and lidocaine conditions. The secondary objectives are evaluating the numerical rating scale (0-10) pain score difference between these two conditions, which would suggest a better outcome if there is an increase in pain scores during the drug free condition; assessing memory performance through signal detection metric d-prime; and determining whether there is a decrease in memory performance with lidocaine compared to the control group."

Answered by AI

Has the administration granted authorization for intravenous lidocaine?

"Taking into account the limited evidence on both safety and efficacy, our team has assigned Lidocaine IV a score of 1."

Answered by AI

Who else is applying?

What state do they live in?
New Jersey
How old are they?
18 - 65
What site did they apply to?
University of Pittsburgh Medical Center
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Neural Correlates of Lidocaine Analgesia
Keith M. Vogt, MD, PhD 2022. "Neural Correlates of Lidocaine Analgesia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05501600.
~13 spots leftby Apr 2025
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