Lidocaine IV for Pain

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Pittsburgh Medical Center, Pittsburgh, PA
Pain+1 More
Lidocaine IV - Drug
Eligibility
18+
All Sexes
What conditions do you have?
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Study Summary

The purpose of this study is to characterize the effects of intravenous lidocaine on pain processing and cognitive function. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will consist of 1 visit and involves no long-term follow up.

Eligible Conditions

  • Pain
  • Anaesthesia therapy

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

4 Primary · 4 Secondary · Reporting Duration: 4.5 minutes

12 minutes
Pain score difference, drug-free condition minus higher-dose lidocaine condition
Pain score difference, drug-free condition minus lower-dose lidocaine condition
3 minutes
Memory performance difference, drug-free minus higher-dose lidocaine condition
Memory performance difference, drug-free minus lower-dose lidocaine condition
4.5 minutes
Brain activation to painful stimulation difference: drug-free condition minus higher-dose lidocaine
Brain activation to painful stimulation difference: drug-free condition minus lower-dose lidocaine
8 minutes
Resting-state functional connectivity difference: drug-free minus higher-dose lidocaine
Resting-state functional connectivity difference: drug-free minus lower-dose lidocaine

Trial Safety

Safety Progress

1 of 3

Trial Design

1 Treatment Group

Lidocaine
1 of 1
Experimental Treatment

30 Total Participants · 1 Treatment Group

Primary Treatment: Lidocaine IV · No Placebo Group · Phase 1

LidocaineExperimental Group · 2 Interventions: Peripheral Nerve Stimulation, Lidocaine IV · Intervention Types: Device, Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Peripheral Nerve Stimulation
2016
N/A
~1350
Lidocaine IV
2020
Completed Phase 4
~90

Trial Logistics

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 4.5 minutes
Closest Location: University of Pittsburgh Medical Center · Pittsburgh, PA
Photo of University of Pittsburgh Medical Center  1Photo of University of Pittsburgh Medical Center  2Photo of University of Pittsburgh Medical Center 3
2001First Recorded Clinical Trial
3 TrialsResearching Pain
580 CompletedClinical Trials

Who is running the clinical trial?

Keith M. Vogt, MD, PhDLead Sponsor
1 Previous Clinical Trials
150 Total Patients Enrolled
1 Trials studying Pain
150 Patients Enrolled for Pain
National Institute of General Medical Sciences (NIGMS)NIH
210 Previous Clinical Trials
90,887 Total Patients Enrolled
7 Trials studying Pain
765 Patients Enrolled for Pain
Keith M Vogt, MD, PhDPrincipal InvestigatorUniversity of Pittsburgh
2 Previous Clinical Trials
182 Total Patients Enrolled
2 Trials studying Pain
182 Patients Enrolled for Pain

Eligibility Criteria

Age 18+ · All Participants · 4 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You are generally healthy.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.