Artemisia annua 450mg for Ovary Cancer

Phase-Based Estimates
1
Effectiveness
1
Safety
University of Kentucky, Lexington, KY
Ovary Cancer+2 More
Artemisia annua 450mg - Drug
Eligibility
18+
Female
Eligible conditions
Ovary Cancer

Study Summary

This study is evaluating whether a specific herb may help treat ovarian cancer.

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Eligible Conditions

  • Ovary Cancer
  • Ovarian Neoplasms
  • Carcinoma, Ovarian Epithelial
  • Ovarian Cancer

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Artemisia annua 450mg will improve 1 primary outcome, 1 secondary outcome, and 6 other outcomes in patients with Ovary Cancer. Measurement will happen over the course of Up to 150 days (baseline and post-treatment).

150 days
Progression Free Survival
Recommended Phase II Dose
Day 150
Change in ABCF2 expression.
Change in CD99 expression.
Change in HO-1 expression.
Change in NQ01 expression.
Change in plasma concentration of artemisinin.
Change in plasma concentration of dihydroartemisinin.

Trial Safety

Safety Estimate

1 of 3

Trial Design

5 Treatment Groups

No Control Group
Dose Expansion - Recommended Phase II Dose

This trial requires 18 total participants across 5 different treatment groups

This trial involves 5 different treatments. Artemisia Annua 450mg is the primary treatment being studied. Participants will be divided into 5 treatment groups. There is no placebo group. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.

Dose Expansion - Recommended Phase II Dose
Drug
This cohort will be an expansion of 6 patients for further tolerability and secondary endpoints analysis. They will consume the recommended phase II dose (dependent on prior analysis).
Dose 5 - 1800mg Artemisia annua
Drug
Participants in this group will consume 4 cups of decaffeinated coffee (1800 mg Artemisia annua).
Dose 1 - 450mg Artemisia annua
Drug
Participants in this group will consume 1 cup of decaffeinated coffee (450 mg Artemisia annua).
Dose 3 - 1350mg Artemisia annua
Drug
Participants in this group will consume 3 cups of decaffeinated coffee (1350 mg Artemisia annua).
Dose 2 - 900mg Artemisia annua
Drug
Participants in this group will consume 2 cups of decaffeinated coffee (900 mg Artemisia annua).

Trial Logistics

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 150 days
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 150 days for reporting.

Closest Location

University of Kentucky - Lexington, KY

Eligibility Criteria

This trial is for female patients aged 18 and older. There are 6 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Total bilirubin ≤ 1.5 x ULN, and AST and ALT ≤ 3.0 x ULN
Able to understand and willing to sign a written informed consent document.
Age ≥ 18 years.
Patients diagnosed with Stage II-IV ovarian cancer who have completed initial first-line therapy with carboplatin and paclitaxel and achieved a complete response.
GOG Performance Status ≤ 2.
Creatinine clearance ≥ 60 mL/min

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What causes ovary cancer?

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The exact cause of ovarian cancer is unknown, but it is believed that the risk of developing ovarian cancer increases as a woman ages. Obesity, an excess accumulation of fat on the abdomen, may increase the risk of developing ovarian cancer when BMI is over 30. Increased levels of estrogen appear to have a role in the development of ovarian cancer. The risk for ovarian cancer is much higher in women who also have a BRCA mutation. Older age and a family history of ovarian cancer do not increase the risk of developing ovarian cancer.

Unverified Answer

What are the signs of ovary cancer?

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The symptoms may be a sign that the cancer is growing and in which stage of development. Symptoms will also vary between different kinds of ovarian cancer. Symptoms of pelvic pain are also a sign of Ovarian cancer and can be a leading sign to get screened. Ovarian cancer can be asymptomatic or cause bowel problems, such as constipation or abdominal pain.

Unverified Answer

How many people get ovary cancer a year in the United States?

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About 7,500 women are diagnosed with [ovarian cancer](https://www.withpower.com/clinical-trials/ovarian-cancer) each year in the United States. Ovary cancer is a debilitating disease and the American Cancer Society estimates that 8,600 women will die of this disease this year.

Unverified Answer

Can ovary cancer be cured?

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The number of case is far less than that of germ cell tumors, most of which are malignant and curable. However, curative treatment is rare due to the short survival time when it is found.

Unverified Answer

What are common treatments for ovary cancer?

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The first-line treatments for ovary cancer were the platinum-based chemotherapy and surgical removal of only part of the ovary with remaining intact and still contained cancer. For patients with metastases, the platinum-based chemotherapy was also effective. It is a challenge to evaluate the outcomes of ovarian cancer patients with other therapies than platinum-based chemotherapy and surgical removal in the future. The quality of future trials needs to incorporate endocrine function as well as toxicity when comparing outcomes between therapies for ovarian cancer.

Unverified Answer

What is ovary cancer?

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[Surgical removal of the ovaries is the therapy of choice in early stage ovarian cancer] (https://www.orthopaediconcology.com/diagnosis-and-treating-of-ovarian-cancer). Discoveries made through clinical trials can help cure patients with early stage ovarian cancer. Power makes it easy to find ovarian cancer clinical trials tailored to your condition, treatment, or location. [Clinicaltrials.

Unverified Answer

What is artemisia annua 450mg?

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Taking A. annua, and the other TCM herbal medicines (or more precisely, combinations of TCM herbal medicines) in this dosage did not prove any superiority compared to the placebo in terms of PSA or other endpoints in a randomized trial of patients with metastatic hormone-refractory PCa.

Unverified Answer

What are the latest developments in artemisia annua 450mg for therapeutic use?

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On the basis of preliminary data in vitro, an increased absorption may be desirable in order to enhance clinical activity if artemisia annua is given in capsules or tablets.

Unverified Answer

Has artemisia annua 450mg proven to be more effective than a placebo?

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While, ARTEMISIA ANNAULa 450 mg was found to be significantly more effective than PLB in improving uterine hormonas, in the end the two groups did not significantly differ in terms of endometrial abnormalities frequency. However, a longer study is needed to study the clinical potential of this herbal preparation.

Unverified Answer

What are the common side effects of artemisia annua 450mg?

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Many side effects were reported by patients but were not frequent; the most frequent side effects were dizziness. It is necessary to educate patients as regards how to use the drug properly.

Unverified Answer

How serious can ovary cancer be?

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Most patients with endometrioid endometriosis have no symptoms or complaints, and they are not aware they have endometriosis. When they have symptoms or a diagnosis, most patients seek medical advice from physicians and nurse-gynecologists, or are prescribed medication without seeing them, as is often done for chronic fatigue syndrome.

Unverified Answer

Does ovary cancer run in families?

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Our finding of an increased risk of ovarian cancer in the father of a woman with ovarian cancer, in this population-based case-control study, suggests that it appears to run in families. The familial susceptibility is probably additive to environmental factors.

Unverified Answer
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