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Insulin

Intranasal insulin for Cardiac Arrest

Phase 1
Waitlist Available
Led By Robert Silbergleit, MD
Research Sponsored by Robert Silbergleit
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, up to 4 hours after drug administration
Awards & highlights

Study Summary

This trial will test the safety of giving insulin via drops in the nostrils to see if it is a tolerable method.

Eligible Conditions
  • Cardiac Arrest
  • Healthy Subjects

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, up to 4 hours after drug administration
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, up to 4 hours after drug administration for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Severe Hypoglycemia as defined by blood glucose < 45 milligrams per deciliter (mg/dL)
Secondary outcome measures
Change in blood glucose
Change in serum C-peptide levels
Change in serum insulin

Side effects data

From 2013 Phase 2 trial • 30 Patients • NCT01206322
7%
Hypertension
100%
80%
60%
40%
20%
0%
Study treatment Arm
Diabetes Group: Placebo
Control Group: Insulin
Diabetes Group: Insulin
Control Group: Placebo

Trial Design

1Treatment groups
Experimental Treatment
Group I: Intranasal insulinExperimental Treatment1 Intervention
A total of 11 possible doses will be tested, ranging from 0 to 1000 U insulin.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Intranasal insulin
2006
Completed Phase 2
~190

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Robert SilbergleitLead Sponsor
1 Previous Clinical Trials
1,023 Total Patients Enrolled
American Heart AssociationOTHER
326 Previous Clinical Trials
4,933,806 Total Patients Enrolled
6 Trials studying Cardiac Arrest
6,954 Patients Enrolled for Cardiac Arrest
Robert Silbergleit, MDPrincipal InvestigatorUniversity of Michigan
3 Previous Clinical Trials
2,012 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Dose-Finding Study of Intranasal Insulin in Healthy Participants Insulin in Healthy Participants
Robert Silbergleit 2021. "Dose-Finding Study of Intranasal Insulin in Healthy Participants Insulin in Healthy Participants". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05062785.
~7 spots leftby Apr 2025
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