← Back to Search

Mesenchymal Stromal Cells

Autologous Adipose-Derived Mesenchymal Stromal Cells for Osteoarthritis

Phase 1
Waitlist Available
Led By Jacob Sellon, MD
Research Sponsored by Jacob L. Sellon, M.D.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years post final injection
Awards & highlights

Study Summary

This trial will test whether it is safe to use a person's own fat cells to treat their knee osteoarthritis.

Eligible Conditions
  • Osteoarthritis of the Knee

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years post final injection
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years post final injection for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of subjects experiencing adverse events.

Trial Design

4Treatment groups
Experimental Treatment
Group I: S50Experimental Treatment1 Intervention
Subjects in the S50 cohort will receive one injection of 50 million AMSCs.
Group II: S100Experimental Treatment1 Intervention
Subjects in the S100 cohort will receive one injection of 100 million AMSCs.
Group III: M50Experimental Treatment1 Intervention
Subjects in the M50 cohort will receive three injections of 50 million AMSCs at one-month intervals.
Group IV: M100Experimental Treatment1 Intervention
Subjects in the M100 cohort will receive three injections of 100 million AMSCs at one-month intervals.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Autologous Adipose-Derived Mesenchymal Stromal Cells
2016
Completed Phase 1
~20

Find a Location

Who is running the clinical trial?

Jacob L. Sellon, M.D.Lead Sponsor
Jacob Sellon, MDPrincipal InvestigatorMayo Clinic
2 Previous Clinical Trials
128 Total Patients Enrolled
1 Trials studying Osteoarthritis
60 Patients Enrolled for Osteoarthritis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Have Autologous Adipose-Derived Mesenchymal Stromal Cells been granted approval by the FDA?

"Autologous Adipose-Derived Mesenchymal Stromal Cells have limited data regarding safety and efficacy, thus it is assigned a score of 1 on our team's scale."

Answered by AI

What are the criteria for enrollment in this research program?

"This clinical trial is welcoming 24 participants with knee osteoarthritis who are between 40 and 70 years old. The key criteria for applicants include successfully completing a 6 week or longer course of conservative treatments (such as activity modification, weight loss, physical therapy etc), being female of childbearing potential but having tested negative on the pregnancy test prior to receiving study drug & agreeing to use adequate contraception from screening until one year post-treatment cycle completion, unilateral symptomatic primary femorotibial OA radiographically proven by two investigators at least KL grade 2 accompanied by joint space narrowing, ability to walk without assistance regularly, clinically stable target knee not"

Answered by AI

Is this investigation accepting new participants at the moment?

"Unfortunately, this trial is no longer recruiting new participants. The study was initially announced on October 26th 2016 and had its last update published April 4th 2022. If you are still looking for research opportunities, there are 692 studies exploring osteoarthritis of the knee actively enrolling as well 33 trials studying Autologous Adipose-Derived Mesenchymal Stromal Cells searching for volunteers."

Answered by AI

How many individuals are participating in this clinical examination?

"This medical trial is not presently recruiting; its first post was on October 26th 2016, and it has been updated most recently on April 4th 2022. For those looking for other related studies, 692 clinical trials are actively enrolling patients with osteoarthritis of the knee while 33 autologous adipose-derived mesenchymal stromal cell studies are also seeking participants."

Answered by AI

Does this clinical research accept minors as participants?

"The study requires that applicants are aged between 40 and 70, with 41 trials for minors and 684 specifically tailored to citizens over 65."

Answered by AI
~2 spots leftby Apr 2025