Methadone for Opioid Use Disorder

"This research is recruiting for 16 individuals, between 18 and 59 years old, who are suffering from drug abuse. The following criteria must be met: Male or female aged ≥18 and ≤59 years; BMI of ≥18 kg/m2 to ≤33 kg/m2; Moderate to severe OUD according DSM-5 standards; Stably engaged in a methadone program with regular attendance and negative urine samples (besides cannabis); Provide contact information for the methadone clinic they attend; Agree that study physician can contact their clinician managing transition into the trial and back out again afterwards.; Be available throughout the entirety of the"

"This clinical trial requires 16 participants who meet the prerequisites. Prospective patients can apply at New york State Psychiatric Institute / Columbia in New York, and Hassman Research Institute, LLC in Berlin, NJ."

"Our team has determined that Methadone is relatively untested, thus it achieved a score of 1. This assessment was based on the fact that this trial is in Phase 1 and there exists limited data to assess its safety or efficacy."

"Correct. According to clinicaltrials.gov, this scientific research endeavour is currently seeking volunteers; it was initially posted on February 28th 2022 and recently updated October 21st 2022. The study requires the participation of 16 individuals across 3 different sites."

"This clinical trial is open to those adults aged 18 and below 59."

"According to the research sponsor, Lyndra Inc., this trial will last 52 days and its primary objective is to ascertain the pharmacokinetics (PK) of levomethadone for LYN-014 at its period of minimum concentration. Additionally, secondary outcomes that need to be measured include ascertaining Cmax (Maximum Concentration), evaluating possible conversion from Levomethadone to Dextromethadone in regards to Cmax (maximum concentration), as well as determining Tmin (Time at Minimum Concentration) concerning the PKs of methadone enantiomers after a dose of methadone."