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Platelet Rich Plasma

Platelet Rich Plasma Injections for Occipital Neuralgia

Phase 1

Waitlist Available

Research Sponsored by University of Calgary

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up pre-injection, 1 month, and 3 month follow-ups.

Awards & highlights

Study Summary

This trial is testing whether a single injection of platelet-rich plasma (PRP) can help people with post-traumatic greater occipital neuralgia.

Eligible Conditions

Headache
Occipital Neuralgia

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ pre-injection, 1 month, and 3 month follow-ups.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~pre-injection, 1 month, and 3 month follow-ups.

This trial's timeline: 3 weeks for screening, Varies for treatment, and pre-injection, 1 month, and 3 month follow-ups. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Evaluate the feasibility of platelet-rich plasma for patients with post-traumatic greater occipital neuralgia

Evaluate the safety profile of platelet-rich plasma for the treatment of post-traumatic greater occipital neuralgia

Secondary outcome measures

Change in headache frequency (days per month with headache).

Change in headache severity as measured by the Numerical Pain Raiting Scale (NPRS)

Headache Impact Test-6

+1 more

Trial Design

3Treatment groups

Experimental Treatment

Active Control

Placebo Group

Group I: Autologous Platelet Rich Plasma InjectionExperimental Treatment1 Intervention

PRP contains high concentrations of platelets, growth factors, and anti-inflammatory molecules.

Group II: Standard TreatmentActive Control1 Intervention

Steroid and anesthetic injection: the clinical standard.

Group III: Normal SalinePlacebo Group1 Intervention

Placebo injection, with no known treatment effects.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Autologous Platelet Rich Plasma Injection

2019

Completed Phase 1

~40

Do I qualify?Apply below to find out

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

University of CalgaryLead Sponsor

790 Previous Clinical Trials

868,323 Total Patients Enrolled

4 Trials studying Headache

271 Patients Enrolled for Headache

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

For what clinical conditions is Autologous Platelet Rich Plasma Injection typically employed?

"Autologous Platelet Rich Plasma Injection is often utilized to treat scalp structure, however it may also be beneficial for minor burns, ulcerative colitis, and transplantation treatments."

Answered by AI

Is this clinical research recruiting participants currently?

"Unfortunately, this clinical trial is not currently recruiting. It was first posted on February 1st 2019 and most recently updated November 3rd 2022. If you are still looking for a study to participate in, there are 291 trials actively seeking people with headache and 261 studies hunting for individuals willing to try Autologous Platelet Rich Plasma Injection treatment."

Answered by AI

Has the Autologous Platelet Rich Plasma Injection gained governmental authorization?

"Due to the preliminary nature of this trial, Autologous Platelet Rich Plasma Injection was assigned a safety rating of 1 on our scale out 3. This reflects that there is some evidence available regarding its efficacy and limited data informing us about its security profile."

Answered by AI

How many participants have been recruited to this clinical trial thus far?

"This clinical investigation has ceased searching for enrollees. The trial first appeared on February 1st 2019 and was last edited November 3rd 2022. Alternately, there are 291 trials examining headache with open recruitment slots and 261 studies of Autologous Platelet Rich Plasma Injection likewise seeking participants."

Answered by AI

Could you please provide a synopsis of the prior research conducted related to Autologous Platelet Rich Plasma Injection?

"Currently, there are 261 clinical trials studying Autologous Platelet Rich Plasma Injection with 69 of them in their third phase. The majority of the studies occur in Duarte, California however a grand total of 7599 centers across the world have been researching this technique."

Answered by AI

Recent research and studies

Brain InjuryJournal

Symptoms and Disability Until 3 Months After Mild TBI

Lundin, A., C. de Boussard, G. Edman, and J. Borg. 2006. “Symptoms and Disability Until 3 Months After Mild TBI”. Brain Injury. Informa UK Limited. doi:10.1080/02699050600744327.

Journal of NeurotraumaJournal

Natural History of Headache After Traumatic Brain Injury

Hoffman, Jeanne M., Sylvia Lucas, Sureyya Dikmen, Cynthia A. Braden, Allen W. Brown, Robert Brunner, Ramon Diaz-Arrastia, William C. Walker, Thomas K. Watanabe, and Kathleen R. Bell. 2011. “Natural History of Headache After Traumatic Brain Injury”. Journal of Neurotrauma. Mary Ann Liebert Inc. doi:10.1089/neu.2011.1914.

Journal of Reconstructive MicrosurgeryJournal

Effect of Platelet-rich Plasma on Peripheral Nerve Regeneration

Sariguney, Yakup, Reha Yavuzer, Cigdem Elmas, Idil Yenicesu, Hayrunisa Bolay, and Kenan Atabay. 2008. “Effect of Platelet-rich Plasma on Peripheral Nerve Regeneration”. Journal of Reconstructive Microsurgery. Georg Thieme Verlag KG. doi:10.1055/s-2008-1076752.

Asian Journal of AndrologyJournal