CLINICAL TRIAL

PUR001 for Cancer

Locally Advanced
Metastatic
Waitlist Available · 18+ · All Sexes · Houston, TX

Safety of PUR001 Monotherapy in Patients With Advanced Solid Tumors

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About the trial for Cancer

Eligible Conditions
Neoplasms · Solid Tumors, Advanced Solid Tumors

Treatment Groups

This trial involves 2 different treatments. PUR001 is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
PUR001
DRUG
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for patients born any sex aged 18 and older. There are 10 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Able to sign informed consent and comply with the protocol
≥ 18 years of age, at the time of signing informed consent
You have no signs or symptoms of cancer. show original
Absolute neutrophil count (ANC) ≥ 1.5 × 109/L
Platelets (plt) ≥ 75 × 109/L
You have a liver metastasis and AST/SGOT and ALT/SGPT are less than 2. show original
You have a total bilirubin ≤ 1.5 × ULN. show original
You have received at least one line of prior systemic chemotherapy and progressed. show original
At least one measurable lesion as defined by RECIST V1.1 criteria for solid tumors. show original
You have hemoglobin (Hgb) ≥ 8 g/dl. show original
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 1-1.5 years
Screening: ~3 weeks
Treatment: Varies
Reporting: 1-1.5 years
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 1-1.5 years.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether PUR001 will improve 1 primary outcome and 12 secondary outcomes in patients with Cancer. Measurement will happen over the course of 1-1.5 years.

Number of participants with treatment-related adverse events (AEs)
1-1.5 YEARS
Safety and tolerability of PUR001 as a single agent. AEs will be assessed per CTCAE v5.0 and may include, but is not limited to, clinically abnormal laboratory tests, physical exams, vital signs, electrocardiograms, and ECOG performance status.
1-1.5 YEARS
Objective Response Rate (ORR)
1-1.5 YEARS
Preliminary efficacy profile of PUR001 as a single agent
1-1.5 YEARS
Volume of Distribution (Vd)
1-1.5 YEARS
Pharmacokinetic (PK) profile of PUR001 as a single agent
1-1.5 YEARS
Area under the concentration time curve (AUC 0-last)
1-1.5 YEARS
Pharmacokinetic (PK) profile of PUR001 as a single agent
1-1.5 YEARS
Half-life (T1/2)
1-1.5 YEARS
Pharmacokinetic (PK) profile of PUR001 as a single agent
1-1.5 YEARS
Progression free survival (PFS)
1-1.5 YEARS
Preliminary efficacy profile of PUR001 as a single agent
1-1.5 YEARS
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Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is cancer?

Cancer is a disease characterized by uncontrolled multiplication of cells that form a mass called a tumor. It is typically divided into two types: malignant or cancerous cancer and benign or non-cancerous cancer. Cancer typically starts in either the lining of the colon or in the tissues around the rectum. The cause of cancers is not fully understood, but they are believed to be the result of some combination of genetic error and environmental factors.\n

Anonymous Patient Answer

What causes cancer?

The exact cause of cancer is unknown, but there are a range of factors that may increase the risk of developing cancer. It is clear that diet and exercise have a protective effect, whereas smoking is both a cause of lung cancer and a risk factor for many benign forms of cancer. A positive family history and early age at first pregnancy increases the risk of breast cancer, as does exposure to ionizing radiation.

Anonymous Patient Answer

What are the signs of cancer?

Symptoms that need to be addressed include blood in the urine, blood in the stool, abdominal pain, itchiness of the skin, unexplained weight loss, and tiredness. The symptoms of cancer may be similar to common and benign conditions; therefore, diagnostic tests may be done if a person presents with these symptoms.\n

Anonymous Patient Answer

How many people get cancer a year in the United States?

The American Cancer Society estimates 235,800 new cases of cancer will be diagnosed in 2022. About 19,000 of these cases will be attributed to tobacco use.

Anonymous Patient Answer

Can cancer be cured?

Cancer can be cured but not in all disease stages or in all disease types. The extent of cure depends on the stage at diagnosis and the disease type of the [prostate cancer](https://www.withpower.com/clinical-trials/prostate-cancer). The extent of cure is probably better when compared to other forms of cancer.

Anonymous Patient Answer

What are common treatments for cancer?

Many cancer treatments cause harm, only lead to temporary relief of symptoms, and not much difference in survival. Common interventions are: surgery or radiotherapy only, surgery and radiotherapy, or no therapy at all. All such options are not optimal treatments and have little effect on survival. Newer treatments for cancer aim to maximize survival and quality of life, rather than just symptom and PSA control. As cancer progresses, there is no cure. Common treatment options for cancer are chemotherapy, radiotherapy and targeted therapy for cancer, which are not effective.

Anonymous Patient Answer

What is the latest research for cancer?

More recent research is published in the field of cancer, but much of the evidence cannot be applied clinically because it is of poor quality and its applicability is questionable.

Anonymous Patient Answer

Is pur001 typically used in combination with any other treatments?

The pur001-pemetrexed combination therapy may increase the median OS and the overall efficacy by more than 3-fold in the treatment of advanced non-small-cell lung cancer patients.

Anonymous Patient Answer

How serious can cancer be?

At a population level, cancer patients are generally not considered to be severely compromised. For a given sex, diagnosis of cancer causes death for half as many men as it does women. Although some aspects of the disease are more life-threatening for men, on average men have a longer life expectancy post-diagnosis than women. The effect of cancer diagnosis on quality of life may, however, vary by gender and the particular disease. Women with breast cancer and ovarian cancer can have severely reduced quality of life as diagnosed and treated. Oncology nurses can help cancer patients address the psychological stresses associated with cancer and its treatment.

Anonymous Patient Answer

What is pur001?

pur001 is one of a group of compounds called purines or purines derivatives. As of 1998 the National Cancer Institute had no evidence to confirm or to disprove any therapeutic use for pur001, but in 1997 a group of scientists began investigating pur001 because of several observations made during preclinical studies by other scientists who were in various stages of cancer therapy. A preclinical study by J. F. Stanger of the University of Colorado, a series of studies by others, and then an observational study of pur001 in cancer patients by G. N. Palanias concluded that pur001 was useful in the treatment of a small group of patients.

Anonymous Patient Answer

Does cancer run in families?

The hypothesis of an inherited component in cancer risk cannot be ruled out in any particular population. However, these findings could be due to shared familial environmental factors influencing both cancer risk and mortality.

Anonymous Patient Answer
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