This trial is evaluating whether REGN3767 will improve 25 primary outcomes and 19 secondary outcomes in patients with Malignancies. Measurement will happen over the course of Baseline to 28 days.
This trial requires 669 total participants across 2 different treatment groups
This trial involves 2 different treatments. REGN3767 is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.
"Regn3767 is safe in the setting of the treatment that we tested for it. Side effects for people with lung cancer and people undergoing chemotherapy may not be associated with Regn3767 as much as those undergoing surgery. There does not seem to be an increased risk of secondary malignancies in patients with lung cancer or people undergoing chemotherapy who are given Regn3767. Recent findings may help guide treatment in future." - Anonymous Online Contributor
"Signs of cancer can include weight loss or increase, itchiness, increased urination, increased sweating, redness and itchiness on the skin. Signs that involve lymph nodes include enlargement of the lymph nodes. Signs of bone cancer involve the symptoms of bone tenderness, warmth, and pain that occur in a single site in the body. Signs of skin cancer include itching, a lump in the skin, or a change in color, shape or size to the skin. Other signs of cancer include changes in bowel habits such as constipation, diarrhoea or abdominal pain or discomfort." - Anonymous Online Contributor
"While some cancers are curable to a great extent, most cancers cannot be cured. But even the curable cancers do better than the non-curable cancer depending on the stage at the time of diagnosis as well as in the number of metastasis and relapse, since patients with non-curable cancer of primary site have a high risk of recurrence compared to patients with curable cancer of primary site." - Anonymous Online Contributor
"Cancer is a disease of the cells of the body. It may be benign (cancer that has not spread), premalignant (cancer that can spread), or malignant (cancer that has already spread). Cancer often appears as tumours, often in the digestive system or respiratory tracts. Some cancers cause no symptoms or cause symptoms that are easy to manage. Others are deadly.\n" - Anonymous Online Contributor
"Approximately 250,000 cases of cancer are diagnosed in the United States each year, making it the most common form of malignancy in men and women." - Anonymous Online Contributor
"The cause and risk factors for cancer are uncertain, although tobacco smoking, in particular, has been linked with cancer in several studies. However, there are many other possible and known environmental risks that impact the development of cancer, including radiation exposure, infections, alcohol and drug use, obesity and metabolic abnormalities. Some types of cancer are associated with genetic predisposition which is sometimes influenced by lifestyle factors. The causes and risk factors for many cancers are not known.\n" - Anonymous Online Contributor
"Cancer patients often receive many different types of therapy to address individual symptoms and to improve cancer-specific symptoms, which includes chemotherapy, anti-cancer medications, and radiation therapy. Many cancer treatments also enhance quality of life. This may include use of adjuvants and cancer drugs to reduce or prolong life." - Anonymous Online Contributor
"In this investigation, there was no evidence to support the use of regn3767 as an additional treatment and there was no clear benefit in terms of overall survival or progression-free time in patients with advanced non small cell lung cancer (NSCLC-NSMC) who were on first line paclitaxel, carboplatin and etoposide chemotherapy." - Anonymous Online Contributor
"In the past 3 years we have been able to identify several compounds that are being tested very soon in a Phase III clinical trial. These drugs may help patients with cancer in the future. If successful, this research will be the first large randomized trial that is looking at the safety and effectiveness of a novel cancer treatment." - Anonymous Online Contributor
"The average age people in the general population develop cancer is 55 years. The mean age people who are diagnosed with cancer is 73 years. Women are diagnosed much earlier than men, especially in the United States. The highest age diagnosed with cancer was in the US was 85 years in 2012, a person diagnosed in the UK in 2014 was 80 years, whereas in Canada and Australia they were 79 and 77 respectively.\n\nThe age people were diagnosed with the highest cancer rates, is not only what is expected it is what we expect to happen." - Anonymous Online Contributor
"The most common side effects for gremlinvastatin in clinical trials were gastrointestinal related (nausea, vomiting, diarrhoea) and were generally transient and tolerable in most cases. There are no clinically significant changes in laboratory parameters or in ECG." - Anonymous Online Contributor
"RGN-3767 may be a drug with an effect on QoL in patients with advanced cancer. The treatment does not affect PFS or overall OS, but does cause some degree of discomfort and an increase in BUN at end of treatment, which could have a negative impact on QoL in patients with high BUN levels. However, these findings need confirmation in larger and longer studies." - Anonymous Online Contributor