Treatment for Musculoskeletal Diseases

Phase-Based Estimates
1
Effectiveness
1
Safety
Duquesne University, Pittsburgh, PA
Musculoskeletal Diseases
Eligibility
18+
All Sexes
Eligible conditions
Musculoskeletal Diseases

Study Summary

This study is evaluating whether a specific type of exercise may help improve bone health, sleep quality, and quality of life for healthy individuals.

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Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Treatment will improve 12 primary outcomes in patients with Musculoskeletal Diseases. Measurement will happen over the course of 0-6 months.

0-6 months
Body Circumference
Bone marker activity-bone formation
Bone marker activity-bone resorption
Functional test 1 to assess musculoskeletal strength
Functional test 2 to assess musculoskeletal strength
Hormone levels-Cortisol
Hormone levels-Testosterone
Inflammatory Marker
Lean Body Mass
Melatonin
Ratio of bone resorption to bone formation
Rest-activity rhythms

Trial Safety

Trial Design

1 Treatment Groups

Control

This trial requires 40 total participants across 1 different treatment groups

This trial involves a single treatment. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

ControlNo treatment in the control group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 0-6 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 0-6 months for reporting.

Closest Location

Duquesne University - Pittsburgh, PA

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Be willing to participate in a 6-month RCT
Be willing to submit specimens and conduct tests 3 times over 6 months (0, 3 and 6 months)
30 years or older (males or females)
Baseline strength (e.g., can lift an office chair with no problems)
Be willing to conduct daily muscle training exercises
Be willing to maintain a food diary
Be willing to consume ~2.2g/kg body weight daily

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is musculoskeletal diseases?

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Musculoskeletal diseases are a widespread and significant group of disorders with varying symptoms. They usually have long and painful histories, but they can produce long-term sequelae and functional problems. The commonness of musculoskeletal disorders and the necessity of comprehensive care make it an effective field of health care.

Unverified Answer

How many people get musculoskeletal diseases a year in the United States?

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Overall health expenditure per capita was highest in Nebraska and lowest in Montana. The strongest state by population with the lowest overall health expenditure per capita was Wyoming.

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Can musculoskeletal diseases be cured?

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A diagnosis of MSMD does not imply cure but is best considered an indication for further action, both therapeutan and orthopaedic. A patient and a family with MSMD should be advised about all the possible treatments and its benefits.

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What are common treatments for musculoskeletal diseases?

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This paper discusses the current evidence for the most effective and effective therapies that can be used for musculoskeletal pain, and those patients who most likely will benefit.

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What are the signs of musculoskeletal diseases?

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There are signs of musculoskeletal diseases, especially joints, at various stages of their disease. However, most of the signs may be asymptomatic. A physical examination may reveal the extent and severity of the musculoskeletal disease.

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What causes musculoskeletal diseases?

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Recent findings reinforces the link between the two conditions and proposes that osteoarthritis, rheumatoid arthritis, and gout are also common in patients. Osteoarthritis is linked to joint trauma, and [knee pain](https://www.withpower.com/clinical-trials/knee-pain) and stiffness are common with gout. Patients also have a family history of arthritic pains or of arthritic gout. Musculoskeletal diseases need to be approached as multi-system disorders, rather than as single diseases with several causes.

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Have there been other clinical trials involving treatment?

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For pain and function, it appears that no clinical trial involving treatments have achieved meaningful improvements over the last 20 years in comparison with placebo. Clinical findings from those studies have been inconsistent, but a possible explanation for this may be the use of low doses of medications over a prolonged period. For disability and quality of life, there have been two clinical trials, one for osteoarthritis and joint replacement, and another for peripheral nerve injury. It is possible that methodological shortcomings may explain the disparity between those clinical trials, that is, the methodologies may not be sufficiently rigorous. For pain and function, for which a positive finding seemed unlikely, the evidence was inconclusive.

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How does treatment work?

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A majority of patients with a chronic low [back pain](https://www.withpower.com/clinical-trials/back-pain) following an acute acute pain episode were adequately assessed at baseline, receiving optimal care. The study showed a non-significant difference between treatments as one of the main outcome measures (functional disability). When compared with other studies, a similar sample size and outcomes is found in the literature. However results should be interpreted cautiously. Better studies are still needed.

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How serious can musculoskeletal diseases be?

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Data from a recent study may be useful for the prevention of occupational musculoskeletal disorders by improving the awareness of occupational exposures and the identification of possible risk factors.

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What are the common side effects of treatment?

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The prevalence of common side effects of treatment in adults with OXO and OSA is similar. Side effects, like the common flu-like symptoms, flu-like symptoms and sore throat occurred more often in patients with OXO, and the two conditions behaved similarly in terms of demographics, comorbidity, severity and clinical status. We did not find differences in the incidence of common side effects of treatment between patients with OXO and those with a different comorbidity.

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Does treatment improve quality of life for those with musculoskeletal diseases?

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For patients with a range of musculoskeletal conditions and disease severity, there is no evidence of any advantage to treatment. Although this study does not measure change in quality of life due to improvements in pain and/or function, or from a cost point of view, we would recommend that treatment should still be considered for patients in a range of musculoskeletal complaints based on their symptoms.

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What are the latest developments in treatment for therapeutic use?

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The past decade has seen a growing number of new, effective treatments for musculoskeletal disorders, and clinicians have taken up to an increasing number of new medical specialty areas. These developments have been achieved with new treatments for acute pain, chronic pain, and for rheumatic disorders with new medications, biologics, and non-biologics. Although these advances have been promising for some areas, there is still much work to be done to find a cure for lumbar disc disease. Current research, however, is making significant progress in that area.

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