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exercise for Myasthenia Gravis

Phase 1
Waitlist Available
Led By Charlene E Hafer-Macko, MD
Research Sponsored by Baltimore VA Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and 3 month
Awards & highlights

Study Summary

Generalized fatigue in myasthenia gravis results in physical deconditioning that reduces fitness and increases risk of obesity, hypertension, elevated cholesterol and type 2 diabetes. This study will examine how active and fit are 30 individuals with chronic, generalized myasthenic subjects. This study will also determine whether a 3 month home exercise program with aerobic, resistive, and pulmonary training can improve physical activity, strength, fitness, lung function and reduce cardiovascular disease risk.

Eligible Conditions
  • Myasthenia Gravis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and 3 month
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 3 month for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Cardiovascular Fitness, Economy of Gait, Physiologic Reserve
Secondary outcome measures
Ambulatory function (6 minute walk, 5 day step activity and accelerometer data)
Body Composition by DEXA and CT of mid-thigh and hip
Cardiovascular risk profile (fasting glucose, oral glucose tolerance test, HbA1c, lipids), smoking status, and body mass index
+4 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: exerciseExperimental Treatment1 Intervention
Multimodal exercises that include walking, breathing exercises, dynamic balance, and core strengthening.

Find a Location

Who is running the clinical trial?

Baltimore VA Medical CenterLead Sponsor
32 Previous Clinical Trials
3,095 Total Patients Enrolled
University of MarylandOTHER
160 Previous Clinical Trials
302,253 Total Patients Enrolled
Charlene E Hafer-Macko, MDPrincipal InvestigatorBaltimore VA Medical Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Exercise for Stable Myasthenia Gravis
Charlene Elaine Hafer-Macko 2010. "Exercise for Stable Myasthenia Gravis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01047761.
All > Myasthenia Gravis
~2 spots leftby Apr 2025
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