Quercetin for Lymphoproliferative Syndrome
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests quercetin, a natural antioxidant, to determine if it can safely reduce inflammation in people with XIAP deficiency, a condition affecting the immune system. Quercetin has decreased inflammation in other diseases, and researchers aim to see if it can help with inflammation linked to this specific condition. The trial is open to male patients diagnosed with XIAP deficiency who have high levels of a specific protein in their blood. Participants will take quercetin twice daily to monitor its effects. As a Phase 1 trial, the research focuses on understanding how quercetin works in people, offering participants the opportunity to be among the first to receive this treatment.
Is there any evidence suggesting that quercetin is likely to be safe for humans?
Research has shown that quercetin is generally safe for people. One study found that participants tolerated quercetin well at various doses, experiencing no major side effects even at the highest doses, similar to those in many dietary supplements. Another study demonstrated that quercetin, a natural antioxidant, was safe for patients with Fanconi anemia, a different health condition. This suggests quercetin might also be safe for individuals with other inflammatory conditions, such as XIAP deficiency. While more research is needed to fully confirm its safety, these findings are encouraging for those considering joining a trial.12345
Why do researchers think this study treatment might be promising?
Unlike standard treatments for lymphoproliferative syndrome, which often involve chemotherapy or immunosuppressive drugs, quercetin is derived from a natural compound found in fruits and vegetables. Researchers are excited because quercetin offers a new mechanism of action; it acts as an antioxidant and anti-inflammatory agent, potentially reducing abnormal cell growth without the harsh side effects typical of traditional therapies. This could mean a more tolerable treatment option that harnesses the power of nature to manage the condition effectively.
What evidence suggests that quercetin might be an effective treatment for lymphoproliferative syndrome?
Research suggests that quercetin might help reduce inflammation related to XIAP deficiency. Studies have shown that quercetin can stop the release of certain inflammatory proteins in cells lacking XIAP, potentially controlling excessive inflammation. Known for its antioxidant properties, quercetin can protect cells from damage. In other conditions, quercetin has shown potential in stabilizing increasing levels of lymphocytes, a type of white blood cell, indicating it may help manage immune responses. While these findings are promising, more research is needed to fully understand quercetin's effectiveness in treating XIAP deficiency. Participants in this trial will receive a weight-adjusted dose of quercetin to evaluate its effects.12467
Who Is on the Research Team?
Rebecca Marsh, MD
Principal Investigator
Children's Hospital Medical Center, Cincinnati
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a weight-adjusted dose of quercetin for a maximum total daily dose of 4000mg/day, divided twice a day
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Quercetin
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
All subjects will receive a weight adjusted dose of quercetin for a maximum total daily dose of 4000mg/day, divided twice a day.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Children's Hospital Medical Center, Cincinnati
Lead Sponsor
Citations
Quercetin ameliorates XIAP deficiency-associated ...
Our data suggest that quercetin may be an effective natural therapeutic for the prevention of XIAP deficiency-associated hyperinflammation.
2.
ashpublications.org
ashpublications.org/blood/article/140/7/706/485525/Quercetin-ameliorates-XIAP-deficiency-associatedQuercetin ameliorates XIAP deficiency–associated ...
05). Our data suggest that quercetin may be an effective natural therapeutic for the prevention of XIAP deficiency-associated hyperinflammation.
Quercetin ameliorates XIAP deficiency–associated ...
Our data suggest that quercetin may be an effective natural therapeutic for the prevention of XIAP deficiency-associated hyperinflammation.
The potential anti-cancer effects of quercetin on blood, ...
The results showed that quercetin combination with rituximab increased apoptosis and cell growth inhibition compared with rituximab mono treatment in WSU-DLCL2 ...
5.
researchgate.net
researchgate.net/publication/353655332_Quercetin_as_a_Novel_Therapeutic_Approach_for_LymphomaQuercetin as a Novel Therapeutic Approach for Lymphoma
In this study, we reviewed the anticancer effects of quercetin and highlighted the potential therapeutic effects of quercetin in various types of lymphoma.
Potential Implications of Quercetin in Autoimmune Diseases
In several recent studies quercetin has reportedly attenuated rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, and systemic lupus ...
Quercetin inhibited LPS-induced cytokine storm by ...
Quercetin could effectively inhibit the overexpression of pro-inflammatory mediators and regulate the AKT1-FoxO1 signaling pathway.
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