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SL-279252 for Cancer
Study Summary
This trial is testing a new drug to treat cancer. It will evaluate how well the drug works and how safe it is.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- You have a certain type of head and neck cancer that started in the mouth, throat or voice box. If your cancer started in other places like the nose or sinuses, you cannot participate.You are physically able to perform everyday activities and take care of yourself without assistance, or you have some symptoms but are still able to carry out daily activities with little assistance.You cannot have had to stop a previous PD-1/L1 therapy due to side effects affecting your immune system.You are currently breastfeeding.You have a mental health condition or life circumstances that may make it difficult for you to follow the study requirements or understand the risks involved.You have had a transplant surgery where someone else's cells or organs were used.You are expected to live for at least 12 more weeks.You have already received two or more treatments that contain checkpoint inhibitors or have been treated with an OX40 agonist before.You cannot receive chemotherapy, immunotherapy, biologic therapy, or hormonal therapy at the same time as the study treatment.You are currently taking corticosteroids or other medications that weaken your immune system, or have taken them within the last 14 days, except for certain cases.You have an autoimmune disease that is currently active or has been diagnosed in the past (with some exceptions).You have a heart condition that is not under control and could affect your health during the study.You are 18 years old or older.You have a type of cancer that cannot be treated with standard therapy or you have tried standard therapy but it didn't work or caused intolerable side effects.You have been diagnosed with one of several types of advanced or metastatic cancers, including melanoma, lung cancer, bladder cancer, head and neck cancer, cervical cancer, stomach cancer, anal cancer, kidney cancer, Hodgkin's lymphoma, or certain types of solid tumors.You are not eligible for the study if you have a certain type of genetic mutation (EGFR sensitizing or ALK fusion) in your non-small cell lung cancer.You can only be part of the study if you meet all of the following requirements.You have given your written permission to take part in the study, following the rules and regulations set by your local authorities.You have tumors that can be measured and tracked by specific medical guidelines called iRECIST or RECIL 2017.You have a type of cancer for which there is no approved standard treatment available, or you have tried standard treatment and it did not work for you, or you cannot receive standard treatment due to intolerances or other reasons.You have an ongoing stomach or intestinal problem that causes symptoms like pain, discomfort, or diarrhea.You have another cancer that needs to be treated and could make it difficult to track your response to the treatment being studied.
- Group 1: SL-279252
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How many research volunteers are involved in the experiment?
"Shattuck Labs, Inc. is requiring a total of 87 patients that meet the inclusion criteria to participate in this trial at multiple sites including The Sarah Cannon Research Institute and The University of Texas MD Anderson Cancer Center."
Is this clinical trial still recruiting participants?
"Clinicaltrials.gov has reported that this experiment is still seeking participants, having originally been published on March 26th 2019 and most recently updated on October 24th 2022."
What detrimental effects has SL-279252 been known to have on those who use it?
"With limited safety and efficacy data, SL-279252 received a score of 1 on the Power assessment scale."
What are the key goals of this clinical investigation?
"The primary aim of this experiment, which will be evaluated from the start to 90 days post treatment (roughly 12 months) is to assess SL-279252's safety profiles in terms of its emergent adverse events. Secondary goals include calculating the drug's Area Under Concentration Curves following single and multiple doses, establishing a recommended phase 2 dose for it, and ascertaining its Volume of Distribution."
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