Loncastuximab + Roflumilast for B-Cell Lymphoma
What You Need to Know Before You Apply
What is the purpose of this trial?
This study is developed by the investigator and is a, phase I, single arm, clinical trial that will enroll subjects with untreated diffuse large B-cell lymphoma (DLCBL) at high risk for poor outcome. The types of treatments given will be shared with participants.The aims are:1. To assess the safety and how well the participants tolerate the treatment2. Assess the response of the tumor to treatment to estimate complete response3. Assess the response of the tumor to treatment to estimate progression-free survival
Who Is on the Research Team?
Ricardo Aguiar, MD
Principal Investigator
The University of Texas Health Science Center at San Antonio
Adolfo E Diaz Duque, MD
Principal Investigator
The University of Texas Health Science Center at San Antonio
Are You a Good Fit for This Trial?
This trial is for adults with untreated high-risk diffuse large B-cell lymphoma (DLBCL). Participants must have a heart function test showing at least 45% efficiency, be able to swallow pills, and have an acceptable general health status. They should not have had previous treatments for lymphoma or other current cancers, except certain localized ones. People with severe allergies to the study drugs or significant medical conditions that increase risk are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Chemotherapy Free Treatment
Participants receive 2 cycles of chemotherapy free therapy composed of Loncastuximab, Rituximab, and Roflumilast
Chemoimmunotherapy
Participants receive 6 cycles of chemoimmunotherapy with R-CHOP, Loncastuximab, and Roflumilast
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Loncastuximab
- Roflumilast
Find a Clinic Near You
Who Is Running the Clinical Trial?
The University of Texas Health Science Center at San Antonio
Lead Sponsor